Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 04 2021
12 04 2021
Historique:
received:
27
08
2020
accepted:
08
03
2021
entrez:
13
4
2021
pubmed:
14
4
2021
medline:
9
11
2021
Statut:
epublish
Résumé
The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it would be positive, and to explore whether genetics may modulate it, using data from a European cohort including 3,407 participants aged 54-79 at high risk of cardiovascular disease. Subclinical atherosclerosis was assessed by carotid intima-media thickness (C-IMT), measured at baseline and after 30 months. Logistic regression (OR; 95% CI) was employed to assess the association between high intake of food rich in saturated fat (vs. low) and: (1) the mean and the maximum values of C-IMT in the whole carotid artery (C-IMT
Identifiants
pubmed: 33846368
doi: 10.1038/s41598-021-86324-w
pii: 10.1038/s41598-021-86324-w
pmc: PMC8042105
doi:
Substances chimiques
Dietary Fats
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7866Investigateurs
C R Sirtori
(CR)
L Calabresi
(L)
M Amato
(M)
B Frigerio
(B)
A Ravani
(A)
D Sansaro
(D)
C Tedesco
(C)
D Coggi
(D)
N Capra
(N)
A Bonomi
(A)
P Eriksson
(P)
J Cooper
(J)
J Acharya
(J)
K Savonen
(K)
K Huttunen
(K)
E Rauramaa
(E)
I M Penttila
(IM)
J Törrönen
(J)
A I van Gessel
(AI)
A M van Roon
(AM)
A Nicolai
(A)
D J Mulder
(DJ)
A Kontush
(A)
A Carrié
(A)
A Gallo
(A)
J Karppi
(J)
T Nurmi
(T)
K Nyyssönen
(K)
T P Tuomainen
(TP)
J Tuomainen
(J)
J Kauhanen
(J)
B Sennblad
(B)
M Pirro
(M)
G Vaudo
(G)
D Siepi
(D)
G Lupattelli
(G)
M R Mannarino
(MR)
V Bianconi
(V)
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