Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection.
Animals
Animals, Newborn
Cystinyl Aminopeptidase
/ metabolism
Disease Models, Animal
Host-Pathogen Interactions
/ immunology
Interferon Type I
/ metabolism
Macrophages, Alveolar
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Respiratory Syncytial Virus Infections
/ immunology
Respiratory Syncytial Viruses
Signal Transduction
Toll-Like Receptors
/ metabolism
Virus Replication
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
31
07
2020
accepted:
22
03
2021
revised:
03
03
2021
pubmed:
14
4
2021
medline:
28
12
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Respiratory Syncytial Virus (RSV) is the major cause of lower respiratory tract infection in infants, in whom, the sensing of RSV by innate immune receptors and its regulation are still poorly described. However, the severe bronchiolitis following RSV infection in neonates has been associated with a defect in type I interferons (IFN-I) production, a cytokine produced mainly by alveolar macrophages (AMs) upon RSV infection in adults. In the present study, neonatal C57BL/6 AMs mobilized very weakly the IFN-I pathway upon RSV infection in vitro and failed to restrain virus replication. However, IFN-I productions by neonatal AMs were substantially increased by the deletion of Insulin-Responsive AminoPeptidase (IRAP), a protein previously involved in the regulation of IFN-I production by dendritic cells. Moreover, neonatal IRAP
Identifiants
pubmed: 33846534
doi: 10.1038/s41385-021-00402-w
pii: S1933-0219(22)00192-1
pmc: PMC8221999
doi:
Substances chimiques
Interferon Type I
0
Toll-Like Receptors
0
Cystinyl Aminopeptidase
EC 3.4.11.3
leucyl-cystinyl aminopeptidase
EC 3.4.11.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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