Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO).

Anti-Bacterial Agents / therapeutic use Antineoplastic Agents / therapeutic use Drug Resistance, Bacterial Fluoroquinolones / therapeutic use Germany Hematologic Neoplasms / complications Hematology Humans Medical Oncology Microbiota / drug effects Pneumocystis carinii / drug effects Pneumonia, Pneumocystis / complications Societies, Medical
Bacterial infections Neutropenia Pneumocystis Prophylaxis Resistance

Journal

Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 21 09 2020
accepted: 04 02 2021
pubmed: 14 4 2021
medline: 27 5 2021
entrez: 13 4 2021
Statut: ppublish

Résumé

Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections and Pneumocystis jirovecii pneumonia (PcP). As bacterial resistances are increasing worldwide and new research reshapes our understanding of the interactions between the human host and bacterial commensals, administration of antibacterial prophylaxis has become a matter of discussion. This guideline constitutes an update of the 2013 published guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). It gives an overview about current strategies for antibacterial prophylaxis in cancer patients while taking into account the impact of antibacterial prophylaxis on the human microbiome and resistance development. Current literature published from January 2012 to August 2020 was searched and evidence-based recommendations were developed by an expert panel. All recommendations were discussed and approved in a consensus conference of the AGIHO prior to publication. As a result, we present a comprehensive update and extension of our guideline for antibacterial and PcP prophylaxis in cancer patients.

Identifiants

DOI: 10.1007/s00277-021-04452-9 PMID: 33846857 PMC: PMC8116237
pubmed: 33846857
doi: 10.1007/s00277-021-04452-9
pii: 10.1007/s00277-021-04452-9
pmc: PMC8116237
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antineoplastic Agents 0
Fluoroquinolones 0

Types de publication

Journal Article Practice Guideline

Langues

eng

Sous-ensembles de citation

IM

Pagination

1603-1620

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Auteurs

Annika Y Classen (AY)

Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany.
German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.

Larissa Henze (L)

Department of Medicine, Clinic III - Hematology, Oncology, Palliative Medicine, Rostock University Medical Center, Rostock, Germany.

Marie von Lilienfeld-Toal (M)

Department of Hematology and Oncology, Clinic for Internal Medicine II, University Hospital Jena, Jena, Germany.

Georg Maschmeyer (G)

Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany.

Michael Sandherr (M)

Specialist Clinic for Haematology and Oncology, Medical Care Center Penzberg, Penzberg, Germany.

Luisa Durán Graeff (LD)

Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany.
German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.

Nael Alakel (N)

Department I of Internal Medicine, Hematology and Oncology, University Hospital Dresden, Dresden, Germany.

Maximilian Christopeit (M)

Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.

Stefan W Krause (SW)

Department of Medicine 5 - Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany.

Karin Mayer (K)

Medical Clinic III for Oncology, Hematology, Immunooncology and Rheumatology, University Hospital Bonn (UKB), Bonn, Germany.

Silke Neumann (S)

Interdisciplinary Center for Oncology, Wolfsburg, Germany.

Oliver A Cornely (OA)

Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany.
German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.

Olaf Penack (O)

Medical Department for Hematology, Oncology and Tumor Immunology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.

Florian Weißinger (F)

Department for Internal Medicine, Hematology/Oncology, and Palliative Care, Evangelisches Klinikum Bethel v. Bodelschwinghsche Stiftungen Bethel, Bielefeld, Germany.

Hans-Heinrich Wolf (HH)

Department IV of Internal Medicine, University Hospital Halle, Halle, Germany.

Jörg Janne Vehreschild (JJ)

Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, University of Cologne, Herderstr. 52-54, 50931, Cologne, Germany. joerg.vehreschild@uk-koeln.de.
German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. joerg.vehreschild@uk-koeln.de.
Department of Internal Medicine, Hematology/Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany. joerg.vehreschild@uk-koeln.de.
ORCID: 0000-0002-5446-7170

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Régions géographiques › Europe › Allemagne › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Hématologie › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Oncologie médicale › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Pneumocystis › Pneumocystis carinii › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumonie à Pneumocystis › Primary prophylaxis of bacterial infections...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Sociétés › Sociétés médicales › Primary prophylaxis of bacterial infections...