SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice.


Journal

Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652

Informations de publication

Date de publication:
03 08 2021
Historique:
pubmed: 14 4 2021
medline: 30 9 2021
entrez: 13 4 2021
Statut: ppublish

Résumé

There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low- and middle-income countries. Here, we report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast (

Identifiants

pubmed: 33847226
doi: 10.1080/21645515.2021.1901545
pmc: PMC8054496
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
COVID-19 Vaccines 0
Spike Glycoprotein, Coronavirus 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2356-2366

Subventions

Organisme : NIAID NIH HHS
ID : P30 AI161943
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI140872
Pays : United States

Commentaires et corrections

Type : UpdateOf

Références

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Auteurs

Jeroen Pollet (J)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Wen-Hsiang Chen (WH)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Leroy Versteeg (L)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Brian Keegan (B)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Bin Zhan (B)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Junfei Wei (J)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Zhuyun Liu (Z)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Jungsoon Lee (J)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Rahki Kundu (R)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Rakesh Adhikari (R)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Cristina Poveda (C)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Maria Jose Villar (MJ)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Ana Carolina de Araujo Leao (AC)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Joanne Altieri Rivera (J)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Zoha Momin (Z)

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Portia M Gillespie (PM)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.

Jason T Kimata (JT)

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Ulrich Strych (U)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Peter J Hotez (PJ)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Department of Biology, Baylor University, Waco, TX, USA.
James A. Baker III Institute for Public Policy, Rice University, Houston, TX, USA.

Maria Elena Bottazzi (ME)

Texas Children's Hospital Center for Vaccine Development, Houston, TX, USA.
Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Department of Biology, Baylor University, Waco, TX, USA.

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Classifications MeSH