Generation of a tissue-specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo.
Keratin 14 promoter
Keratin 8 - Serine73
/431 phosphorylation
skin carcinogenesis
transgenic mice
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
10
04
2021
received:
09
02
2021
accepted:
12
04
2021
pubmed:
14
4
2021
medline:
24
12
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Keratin 8/18, the predominant keratin pair of simple epithelia, is known to be aberrantly expressed in several squamous cell carcinomas (SCCs), where its expression is often correlated with increased invasion, neoplastic progression, and poor prognosis. The majority of keratin 8/18 structural and regulatory functions are governed by posttranslational modifications, particularly phosphorylation. Apart from filament reorganization, cellular processes including cell cycle, cell growth, cellular stress, and apoptosis are known to be orchestrated by K8 phosphorylation at specific residues in the head and tail domains. Even though deregulation of K8 phosphorylation at two significant sites (Serine
Substances chimiques
Keratin-8
0
Krt8 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1720-1732Informations de copyright
© 2021 International Federation for Cell Biology.
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