Vessel-related structures predict UIP pathology in those with a non-IPF pattern on CT.
Interstitial lung disease
Multidetector computed tomography
Usual interstitial pneumonia
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
12
05
2020
accepted:
10
03
2021
revised:
23
12
2020
pubmed:
14
4
2021
medline:
23
9
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
To determine if a quantitative imaging variable (vessel-related structures [VRS]) could identify subjects with a non-IPF diagnosis CT pattern who were highly likely to have UIP histologically. Subjects with a multidisciplinary diagnosis of interstitial lung disease including surgical lung biopsy and chest CT within 1 year of each other were included in the study. Non-contrast CT scans were analyzed using the Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER) program, which quantifies the amount of various abnormal CT patterns on chest CT. Quantitative data were analyzed relative to pathological diagnosis as well as the qualitative CT pattern. CALIPER-derived volumes of reticulation (p = 0.012), honeycombing (p = 0.017), and VRS (p < 0.001) were associated with a UIP pattern on pathology on univariate analysis but only VRS was associated with a UIP pathology on multivariable analysis (p = 0.013). Using a VRS cut-off of 173 cm VRS may be an adjunct to CT in predicting pathology in patients with interstitial lung disease. • Volume of vessel-related structures (VRS) was associated with usual interstitial pneumonia (UIP) on pathology. • This differentiation arose from those with CT scans with a non-IPF diagnosis imaging pattern. • Higher VRS has similar diagnostic ramifications for UIP as probable UIP, transitively suggesting in patients with high VRS, pathology may be obviated.
Identifiants
pubmed: 33847810
doi: 10.1007/s00330-021-07861-6
pii: 10.1007/s00330-021-07861-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7295-7302Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. European Society of Radiology.
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