Th1/Th2 imbalance and heat shock protein mediated inflammatory damage triggered by manganese via activating NF-κB pathway in chicken nervous system in vivo and in vitro.
Chicken nervous system
Environmental pollutant manganese
Heat shock protein
Inflammatory injury
Th1/Th2 imbalance
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
06
10
2020
accepted:
30
03
2021
pubmed:
14
4
2021
medline:
14
8
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Manganese (Mn) is a ubiquitous heavy metal pollutant in environment, and excess Mn can damage nervous system of humans and animals. However, molecular mechanism of Mn-induced poultry neurotoxicity on inflammatory injury is still not fully clear. Thus, the purpose of the conducted research was to explore molecular mechanism of inflammatory injury caused by Mn in chicken nervous system. Two Mn poisoning models were established in vivo and in vitro. One hundred and eighty chickens were randomly separated into four groups. One control group was raised drinking water and standard diet. Three Mn groups were raised drinking water, and the standard diet supplemented with three different concentrations of MnCl
Identifiants
pubmed: 33847884
doi: 10.1007/s11356-021-13782-0
pii: 10.1007/s11356-021-13782-0
doi:
Substances chimiques
Heat-Shock Proteins
0
Manganese
42Z2K6ZL8P
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44361-44373Subventions
Organisme : National Natural Science Foundation of China
ID : No. 31972612
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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