Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat.
Arsenic-containing hydrocarbon
Arsenolipids
In vitro
Long-term potentiation
Neurotoxicity
Schaffer Collateral-CA1 synapses
Journal
Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
12
01
2021
revised:
25
03
2021
accepted:
07
04
2021
pubmed:
14
4
2021
medline:
15
12
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Arsenic-containing hydrocarbons (AsHCs) are common constituents of marine organisms and have potential toxicity to human health. This work is to study the effect of AsHCs on long-term potentiation (LTP) for the first time. A multi-electrode array (MEA) system was used to record the field excitatory postsynaptic potential (fEPSP) of CA1 before and after treatment with AsHC 360 in hippocampal slices from infantile male rats. The element content of Na, K, Ca, Mg, Mn, Cu, Zn, and As in the hippocampal slices were analyzed by elemental mass spectrometry after the neurophysiological experiment. The results showed that low AsHC 360 (1.5 μg As L
Identifiants
pubmed: 33848561
pii: S0161-813X(21)00036-X
doi: 10.1016/j.neuro.2021.04.002
pii:
doi:
Substances chimiques
Hydrocarbons
0
Arsenic
N712M78A8G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
198-207Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.