Proteomic characterization of the human lens and Cataractogenesis.
Lens
aging
cataract
long-lived proteins
mass spectrometry
spatial proteomics
Journal
Expert review of proteomics
ISSN: 1744-8387
Titre abrégé: Expert Rev Proteomics
Pays: England
ID NLM: 101223548
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
15
4
2021
medline:
3
2
2022
entrez:
14
4
2021
Statut:
ppublish
Résumé
The goal of this review is to highlight the triumphs and frontiers in measurement of the lens proteome as it relates to onset of age-related nuclear cataract. As global life expectancy increases, so too does the frequency of age-related nuclear cataracts. Molecular therapeutics do not exist for delay or relief of cataract onset in humans. Since lens fiber cells are incapable of protein synthesis after initial maturation, age-related changes in proteome composition and post-translational modification accumulation can be measured with various techniques. Several of these modifications have been associated with cataract onset. We discuss the impact of long-lived proteins on the lens proteome and lens homeostasis as well as proteomic techniques that may be used to measure proteomes at various levels of proteomic specificity and spatial resolution. There is clear evidence that several proteome modifications are correlated with cataract formation. Past studies should be enhanced with cutting-edge, spatially resolved mass spectrometry techniques to enhance the specificity and sensitivity of modification detection as it relates to cataract formation.
Identifiants
pubmed: 33849365
doi: 10.1080/14789450.2021.1913062
pmc: PMC9227965
mid: NIHMS1813070
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-135Subventions
Organisme : NEI NIH HHS
ID : R01 EY024258
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013462
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY008126
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM065086
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013463
Pays : United States
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