Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients.
Clinical signs of seizure
Coenzyme Q10
Epileptic seizures
Oxidative stress
Journal
Basic and clinical neuroscience
ISSN: 2008-126X
Titre abrégé: Basic Clin Neurosci
Pays: Iran
ID NLM: 101575211
Informations de publication
Date de publication:
Historique:
received:
27
10
2018
revised:
20
11
2018
accepted:
23
04
2019
entrez:
14
4
2021
pubmed:
15
4
2021
medline:
15
4
2021
Statut:
ppublish
Résumé
Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear. The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure. A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels. These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.
Identifiants
pubmed: 33850613
doi: 10.32598/bcn.11.6.1100.1
pii: bcn-11-765
pmc: PMC8019840
doi:
Types de publication
Journal Article
Langues
eng
Pagination
765-771Informations de copyright
Copyright© 2020 Iranian Neuroscience Society.
Déclaration de conflit d'intérêts
Conflict of interest The authors declared no conflict of interest.
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