Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats.
Eating
Food intake
SKF38393
Ventral Tegmental Area
Journal
Basic and clinical neuroscience
ISSN: 2008-126X
Titre abrégé: Basic Clin Neurosci
Pays: Iran
ID NLM: 101575211
Informations de publication
Date de publication:
Historique:
received:
24
11
2019
revised:
10
12
2019
accepted:
26
01
2020
entrez:
14
4
2021
pubmed:
15
4
2021
medline:
15
4
2021
Statut:
ppublish
Résumé
Ventral Tegmental Area (VTA) dopamine neurons play an important role in reward mechanisms of food intake, and VTA dopamine receptors exist on the terminal of glutamatergic and GABAergic neurons and regulate Gamma-Aminobutyric Acid (GABA) and glutamate release. To our knowledge, no evidence indicates any role for VTA D1 dopamine receptors in regular chow intake. In this paper, different dose of SKF38393, a D1 receptor agonist, was microinjected in VTA of 18-h food deprived-conscious rats and food intake was measured. Our results revealed that VTAmicroinjected SKF383993 increased regular chow intake in a dose-dependent manner. The SKF3833 stimulatory effect persisted over 2 h post-injection. The results showed that the SKF38393, at doses less than 5 μg, did not affect locomotor activities. VTA D1-like and/or serotonergic receptors may be involved in regulatory pathways. the current study suggests that VTA D1-like and/or serotonergic receptors not only affects food reward but is also involved in regulatory mechanisms of regular feeding.
Identifiants
pubmed: 33850614
doi: 10.32598/bcn.11.6.2226.1
pii: bcn-11-773
pmc: PMC8019846
doi:
Types de publication
Journal Article
Langues
eng
Pagination
773-780Informations de copyright
Copyright© 2020 Iranian Neuroscience Society.
Déclaration de conflit d'intérêts
Conflict of interest The authors declared no conflict of interest.
Références
Neuroscience. 2014 Dec 12;282:60-8
pubmed: 24875175
J Neurosci. 1995 Sep;15(9):5859-69
pubmed: 7666171
J Comp Neurol. 1978 Aug 1;180(3):545-80
pubmed: 659674
Lancet. 2001 Feb 3;357(9253):354-7
pubmed: 11210998
Brain Res Bull. 1982 Jun;8(6):685-91
pubmed: 7139361
Physiol Behav. 1986;38(6):773-9
pubmed: 3103150
Annu Rev Neurosci. 2007;30:367-98
pubmed: 17506645
Nature. 1993 Nov 25;366(6453):344-7
pubmed: 8247128
Eur J Pharmacol. 1990 Jun 12;188(6):335-47
pubmed: 1973652
Science. 1992 Oct 23;258(5082):597-603
pubmed: 1329206
J Neural Transm Suppl. 1993;40:1-12
pubmed: 7905022
J Pharmacol Exp Ther. 1995 Apr;273(1):101-12
pubmed: 7714755
Brain Res Mol Brain Res. 1994 Apr;23(1-2):163-78
pubmed: 8028479
Cell. 1995 Dec 29;83(7):1197-209
pubmed: 8548806
J Neurosci. 1995 Jul;15(7 Pt 2):5379-88
pubmed: 7623160
J Neurosci. 1992 Jul;12(7):2623-32
pubmed: 1319478
Synapse. 2000 Aug;37(2):125-45
pubmed: 10881034
Nat Rev Neurosci. 2004 Jun;5(6):483-94
pubmed: 15152198
Psychopharmacology (Berl). 1992;107(2-3):285-9
pubmed: 1615127
J Neurophysiol. 1994 Aug;72(2):1024-7
pubmed: 7983508
Int J Obes. 1984;8 Suppl 1:39-50
pubmed: 6398807
Neurosci Lett. 1980 Jun;18(2):125-31
pubmed: 7052484
Curr Opin Neurobiol. 1997 Apr;7(2):191-7
pubmed: 9142754
Brain Res. 1978 Aug 25;152(2):215-47
pubmed: 354753
Gen Pharmacol. 1991;22(6):1011-6
pubmed: 1687390
Nat Rev Neurosci. 2006 Dec;7(12):967-75
pubmed: 17115078
Neuroscience. 2008 Jun 2;153(4):1213-24
pubmed: 18455318
J Neurosci. 2007 May 23;27(21):5730-43
pubmed: 17522317
Neuroscience. 2000;100(4):689-99
pubmed: 11036203
Neuroscience. 2002;109(3):585-95
pubmed: 11823068
Brain Res. 2005 Feb 8;1033(2):179-85
pubmed: 15694922
Nat Neurosci. 2014 Nov;17(11):1543-51
pubmed: 25242304
Brain Res Bull. 1989 Apr;22(4):725-35
pubmed: 2736398
Brain Res Brain Res Rev. 1993 Jan-Apr;18(1):75-113
pubmed: 8096779
Eur J Pharmacol. 2018 Jan 5;818:43-49
pubmed: 29056523
Brain Res Rev. 2007 Nov;56(1):27-78
pubmed: 17574681
Nature. 1991 Apr 18;350(6319):614-9
pubmed: 1826762
Brain Res. 1976 Apr 16;106(1):133-45
pubmed: 1268702
Trends Neurosci. 2007 Aug;30(8):375-81
pubmed: 17604133
Eur J Neurosci. 2002 Nov;16(10):1987-93
pubmed: 12453062
Brain Res. 1980 Oct 20;199(2):466-73
pubmed: 7417797
Nature. 1991 Apr 18;350(6319):610-4
pubmed: 1840645
J Neurosci. 2008 Jul 30;28(31):7797-807
pubmed: 18667612
Behav Brain Res. 2014 Oct 1;272:279-85
pubmed: 25017572
J Pharmacol Exp Ther. 1984 Nov;231(2):275-80
pubmed: 6491980
J Neurophysiol. 1992 Jan;67(1):145-63
pubmed: 1552316
Neuropharmacology. 1987 Jun;26(6):613-9
pubmed: 2955244
J Comp Neurol. 2005 Mar 7;483(2):217-35
pubmed: 15678476
Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1149-58
pubmed: 16874930
Synapse. 1997 Feb;25(2):205-14
pubmed: 9021901
J Comp Neurol. 1996 Jan 08;364(2):231-53
pubmed: 8788247
Nature. 2012 Nov 8;491(7423):212-7
pubmed: 23064228