Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
HBM4EU
LDL
PFOA
PFOS
cholesterol
hepatocytes
lipid perturbation
lipoprotein metabolism
serum levels
triglycerides
Journal
Critical reviews in toxicology
ISSN: 1547-6898
Titre abrégé: Crit Rev Toxicol
Pays: England
ID NLM: 8914275
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
16
4
2021
medline:
4
8
2021
entrez:
15
4
2021
Statut:
ppublish
Résumé
Associations between per- and polyfluoroalkyl substances (PFASs) and increased blood lipids have been repeatedly observed in humans, but a causal relation has been debated. Rodent studies show reverse effects, i.e. decreased blood cholesterol and triglycerides, occurring however at PFAS serum levels at least 100-fold higher than those in humans. This paper aims to present the main issues regarding the modulation of lipid homeostasis by the two most common PFASs, PFOS and PFOA, with emphasis on the underlying mechanisms relevant for humans. Overall, the apparent contrast between human and animal data may be an artifact of dose, with different molecular pathways coming into play upon exposure to PFASs at very low
Identifiants
pubmed: 33853480
doi: 10.1080/10408444.2021.1888073
doi:
Substances chimiques
Alkanesulfonic Acids
0
Caprylates
0
Environmental Pollutants
0
Fluorocarbons
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM