Promotion of Surgical Masks Antimicrobial Activity by Disinfection and Impregnation with Disinfectant Silver Nanoparticles.
Animals
Anti-Infective Agents
/ administration & dosage
Antiviral Agents
/ chemistry
COVID-19
/ prevention & control
Chick Embryo
Disinfectants
/ administration & dosage
Disinfection
/ methods
Dynamic Light Scattering
Equipment Reuse
Humans
Influenza A Virus, H5N1 Subtype
/ drug effects
Masks
/ virology
Metal Nanoparticles
/ administration & dosage
Microbial Sensitivity Tests
Silver
/ chemistry
Spectroscopy, Fourier Transform Infrared
Textiles
X-Ray Diffraction
COVID-19
SARS-CoV-2
antimicrobial
nanobiotechnology
nanoparticles
surgical mask
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
01
2021
accepted:
19
03
2021
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
4
5
2021
Statut:
epublish
Résumé
The COVID-19 pandemic is requesting highly effective protective personnel equipment, mainly for healthcare professionals. However, the current demand has exceeded the supply chain and, consequently, shortage of essential medical materials, such as surgical masks. Due to these alarming limitations, it is crucial to develop effective means of disinfection, reusing, and thereby applying antimicrobial shielding protection to the clinical supplies. Therefore, in this work, we developed a novel, economical, and straightforward approach to promote antimicrobial activity to surgical masks by impregnating silver nanoparticles (AgNPs). Our strategy consisted of fabricating a new alcohol disinfectant formulation combining special surfactants and AgNPs, which is demonstrated to be extensively effective against a broad number of microbial surrogates of SARS-CoV-2. The present nano-formula reported a superior microbial reduction of 99.999% against a wide number of microorganisms. Furthermore, the enveloped H5N1 virus was wholly inactivated after 15 min of disinfection. Far more attractive, the current method for reusing surgical masks did not show outcomes of detrimental amendments, suggesting that the protocol does not alter the filtration effectiveness. The nano-disinfectant provides a valuable strategy for effective decontamination, reuse, and even antimicrobial promotion to surgical masks for frontline clinical personnel.
Sections du résumé
BACKGROUND
BACKGROUND
The COVID-19 pandemic is requesting highly effective protective personnel equipment, mainly for healthcare professionals. However, the current demand has exceeded the supply chain and, consequently, shortage of essential medical materials, such as surgical masks. Due to these alarming limitations, it is crucial to develop effective means of disinfection, reusing, and thereby applying antimicrobial shielding protection to the clinical supplies.
PURPOSE
OBJECTIVE
Therefore, in this work, we developed a novel, economical, and straightforward approach to promote antimicrobial activity to surgical masks by impregnating silver nanoparticles (AgNPs).
METHODS
METHODS
Our strategy consisted of fabricating a new alcohol disinfectant formulation combining special surfactants and AgNPs, which is demonstrated to be extensively effective against a broad number of microbial surrogates of SARS-CoV-2.
RESULTS
RESULTS
The present nano-formula reported a superior microbial reduction of 99.999% against a wide number of microorganisms. Furthermore, the enveloped H5N1 virus was wholly inactivated after 15 min of disinfection. Far more attractive, the current method for reusing surgical masks did not show outcomes of detrimental amendments, suggesting that the protocol does not alter the filtration effectiveness.
CONCLUSION
CONCLUSIONS
The nano-disinfectant provides a valuable strategy for effective decontamination, reuse, and even antimicrobial promotion to surgical masks for frontline clinical personnel.
Identifiants
pubmed: 33854315
doi: 10.2147/IJN.S301212
pii: 301212
pmc: PMC8039202
doi:
Substances chimiques
Anti-Infective Agents
0
Antiviral Agents
0
Disinfectants
0
Silver
3M4G523W1G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2689-2702Informations de copyright
© 2021 Valdez-Salas et al.
Déclaration de conflit d'intérêts
Dr Benjamin Valdez-Salas and Dr Ernesto Beltran-Partida report grants from Consejo Nacional De Ciencia Y Tecnologia, during the conduct of the study. The authors declare no other competing interest regarding the publication of this work.
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