Effect of GLP-1/GLP-1R on the Polarization of Macrophages in the Occurrence and Development of Atherosclerosis.
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
01
2021
revised:
22
02
2021
accepted:
08
03
2021
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
15
12
2021
Statut:
epublish
Résumé
To investigate the effect of GLP-1/GLP-1R on the polarization of macrophages in the occurrence and development of atherosclerosis. Totally, 49 patients with coronary heart disease (CHD) and 52 cases of health control (HC) were recruited, all subjects accept coronary angiography gold standard inspection. One or more major coronary arteries (LM, LAD, LCx, and RCA) stenosis degree in 50% of patients as CHD group; the rest of the stenosis less than 50% or not seen obvious stenosis are assigned to the HC group. Flow cytometry were used to detect the percentage of (CD14+) M macrophages, (CD14+CD80+) M1 macrophages, (CD14+CD206+) M2 macrophages, and their surface GLP-1R expression differences in the two groups, using BD cytokine kit to detect the levels of IL-8, IL-1 GLP-1R expression on the surface of total macrophages and M2 macrophages was different between the CHD group and the HC group ( GLP-1R agonist is independent of the hypoglycemic effect of T2DM and has protective effect on cardiovascular system. GLP-1R may regulate the polarization of macrophages toward M2, thus playing a protective role in the progression of coronary atherosclerosis.
Identifiants
pubmed: 33854404
doi: 10.1155/2021/5568159
pmc: PMC8019627
doi:
Substances chimiques
Cytokines
0
Glucagon-Like Peptide-1 Receptor
0
Lipids
0
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5568159Informations de copyright
Copyright © 2021 Li Yang et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
J Aging Res. 2020 Mar 21;2020:7417242
pubmed: 32280543
Circ Res. 2020 Jul 17;127(3):335-353
pubmed: 32336197
Eur J Clin Invest. 2020 Feb;50(2):e13195
pubmed: 31868918
Front Endocrinol (Lausanne). 2019 Apr 12;10:155
pubmed: 31031702
Biochem Biophys Res Commun. 2012 Aug 24;425(2):304-8
pubmed: 22842565
J Am Heart Assoc. 2017 Oct 24;6(10):
pubmed: 29066452
J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145
pubmed: 32771263
Diabetes Obes Metab. 2021 Jan;23(1):195-207
pubmed: 33001570
Front Biosci (Landmark Ed). 2017 Jan 1;22:504-515
pubmed: 27814628
Circulation. 2008 Dec 16;118(25):2687-93
pubmed: 19106391
Lancet. 2019 Jul 13;394(10193):121-130
pubmed: 31189511
Eye (Lond). 2020 Oct;34(10):1941-1942
pubmed: 32699378
Int J Clin Exp Pathol. 2015 Feb 01;8(2):2214-20
pubmed: 25973132
J Inflamm (Lond). 2020 Oct 31;17(1):35
pubmed: 33292260
Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):145-158
pubmed: 31747801
J Intern Med. 2004 Nov;256(5):421-8
pubmed: 15485478
Cell Rep. 2018 Nov 20;25(8):2044-2052.e5
pubmed: 30463003
Nat Rev Cardiol. 2020 Apr;17(4):216-228
pubmed: 31578516
Cardiovasc Drugs Ther. 2014 Oct;28(5):425-32
pubmed: 25022544
Annu Rev Immunol. 2009;27:451-83
pubmed: 19105661
Nat Rev Cardiol. 2020 Jul;17(7):387-401
pubmed: 32203286
Cytokine. 2019 Oct;122:154385
pubmed: 29703573
Atherosclerosis. 2019 Aug;287:181-183
pubmed: 31104809
Adv Clin Chem. 2017;82:47-70
pubmed: 28939213
Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H109-20
pubmed: 24163071
Rev Clin Esp. 2019 Aug - Sep;219(6):293-302
pubmed: 30773286
Eur Heart J. 2020 Jan 1;41(1):111-188
pubmed: 31504418
PLoS One. 2014 Apr 10;9(4):e92964
pubmed: 24722336
Arch Biochem Biophys. 2019 Aug 15;671:203-209
pubmed: 31302140
Eur Heart J. 2014 Mar;35(9):578-89
pubmed: 24026779
Diabetologia. 2011 Nov;54(11):2745-54
pubmed: 21744074