Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice.
adipose tissue
arterial stiffening
endothelium
inflammation
macrophage
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
07
2020
accepted:
17
02
2021
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
16
4
2021
Statut:
epublish
Résumé
Enhanced mineralocorticoid receptor (MR) signaling is critical to the development of endothelial dysfunction and arterial stiffening. However, there is a lack of knowledge about the role of MR-induced adipose tissue inflammation in the genesis of vascular dysfunction in women. In this study, we hypothesize that MR activation in myeloid cells contributes to angiotensin II (Ang II)-induced aortic stiffening and endothelial dysfunction in females
Identifiants
pubmed: 33854438
doi: 10.3389/fphys.2021.588358
pmc: PMC8039313
doi:
Types de publication
Journal Article
Langues
eng
Pagination
588358Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL132012
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088105
Pays : United States
Organisme : BLRD VA
ID : I01 BX003391
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142770
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124155
Pays : United States
Organisme : BLRD VA
ID : I01 BX001981
Pays : United States
Informations de copyright
Copyright © 2021 Manrique-Acevedo, Padilla, Naz, Woodford, Ghiarone, Aroor, Hulse, Cabral-Amador, Martinez-Diaz, Hans, Whaley-Connell, Martinez-Lemus and Lastra.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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