Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in burning mouth syndrome patients with or without microcytosis.
Anemia
Burning mouth syndrome
Hyperhomocysteinemia
Iron
Microcytosis
Journal
Journal of dental sciences
ISSN: 2213-8862
Titre abrégé: J Dent Sci
Pays: Netherlands
ID NLM: 101293181
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
20
12
2020
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
16
4
2021
Statut:
ppublish
Résumé
Microcytosis is defined as having mean corpuscular volume <80 fL. This study evaluated whether 68 burning mouth syndrome (BMS) patients with microcytosis and 816 BMS patients without microcytosis had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 442 healthy control subjects. Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 68 BMS patients with microcytosis, 816 BMS patients without microcytosis, and 442 healthy control subjects were measured and compared. We found that 73.5%, 44.1%, 4.4%, 2.9%, 13.2%, and 10.3% of 68 BMS patients with microcytosis and 15.3%, 13.8%, 4.8%, 2.2%, 19.7%, and 12.5% of 816 BMS patients without microcytosis had blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 68 BMS patients with microcytosis and 816 BMS patients without microcytosis had significantly higher frequencies of blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in BMS patients with or without microcytosis than in healthy control subjects. BMS patients with microcytosis have significantly higher frequencies of blood hemoglobin and iron deficiencies than BMS patients without microcytosis.
Sections du résumé
BACKGROUND/PURPOSE
OBJECTIVE
Microcytosis is defined as having mean corpuscular volume <80 fL. This study evaluated whether 68 burning mouth syndrome (BMS) patients with microcytosis and 816 BMS patients without microcytosis had higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 442 healthy control subjects.
MATERIALS AND METHODS
METHODS
Complete blood count and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 68 BMS patients with microcytosis, 816 BMS patients without microcytosis, and 442 healthy control subjects were measured and compared.
RESULTS
RESULTS
We found that 73.5%, 44.1%, 4.4%, 2.9%, 13.2%, and 10.3% of 68 BMS patients with microcytosis and 15.3%, 13.8%, 4.8%, 2.2%, 19.7%, and 12.5% of 816 BMS patients without microcytosis had blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Both 68 BMS patients with microcytosis and 816 BMS patients without microcytosis had significantly higher frequencies of blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all
CONCLUSION
CONCLUSIONS
There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in BMS patients with or without microcytosis than in healthy control subjects. BMS patients with microcytosis have significantly higher frequencies of blood hemoglobin and iron deficiencies than BMS patients without microcytosis.
Identifiants
pubmed: 33854709
doi: 10.1016/j.jds.2020.12.009
pii: S1991-7902(20)30286-5
pmc: PMC8025219
doi:
Types de publication
Journal Article
Langues
eng
Pagination
608-613Informations de copyright
© 2021 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest relevant to this article.
Références
J Formos Med Assoc. 2020 Dec;119(12):1758-1763
pubmed: 32883568
Hematology Am Soc Hematol Educ Program. 2012;2012:183-90
pubmed: 23233579
Am Fam Physician. 2000 Nov 15;62(10):2255-64
pubmed: 11126852
J Dent Sci. 2020 Jun;15(2):214-221
pubmed: 32595904
J Formos Med Assoc. 2014 Feb;113(2):83-7
pubmed: 24388269
J Formos Med Assoc. 2017 Aug;116(8):613-619
pubmed: 28314600
Am J Clin Nutr. 2007 Jan;85(1):193-200
pubmed: 17209196
J Oral Pathol Med. 2016 Jan;45(1):23-7
pubmed: 25990467
J Oral Pathol Med. 2013 Jul;42(6):474-9
pubmed: 23297780
J Formos Med Assoc. 2013 Dec;112(12):761-5
pubmed: 24139948
J Dent Sci. 2020 Mar;15(1):34-41
pubmed: 32256998
Blood Rev. 2014 Mar;28(2):49-66
pubmed: 24560123
J Formos Med Assoc. 2015 Sep;114(9):806-12
pubmed: 26187724
Am Fam Physician. 1997 May 15;55(7):2455-62
pubmed: 9166144
Blood Rev. 1989 Dec;3(4):211-5
pubmed: 2692743
J Formos Med Assoc. 2020 Jan;119(1 Pt 3):544-552
pubmed: 31444017
Br Med J. 1962 Nov 24;2(5316):1347-52
pubmed: 13993616
Arch Pharm Res. 2018 Apr;41(4):372-383
pubmed: 29552692
Oral Dis. 2013 May;19(4):381-6
pubmed: 22957902
Oral Dis. 2013 Jul;19(5):519-24
pubmed: 23130817
Food Nutr Bull. 2008 Jun;29(2 Suppl):S238-44
pubmed: 18709899
N Engl J Med. 2006 Apr 13;354(15):1567-77
pubmed: 16531613
Lancet Neurol. 2007 Sep;6(9):830-8
pubmed: 17706567
J Formos Med Assoc. 2015 Jun;114(6):532-8
pubmed: 25886860
Acta Clin Croat. 2014 Sep;53(3):348-54
pubmed: 25509246
J Dent Sci. 2020 Mar;15(1):42-49
pubmed: 32256999
Stem Cells. 1995 Jan;13(1):32-7
pubmed: 7719246
Hematol Oncol Clin North Am. 2014 Aug;28(4):671-81, vi
pubmed: 25064707
J Formos Med Assoc. 2021 Feb;120(2):819-826
pubmed: 32888843