Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial.
Adult
Body Mass Index
Cholesterol, HDL
/ metabolism
Cross-Over Studies
Diabetes Mellitus, Type 1
/ complications
Diet, Carbohydrate-Restricted
Dyslipidemias
/ etiology
Female
Humans
Lipid Metabolism
Lipidomics
/ methods
Male
Middle Aged
Phosphatidylcholines
/ metabolism
Sphingomyelins
/ metabolism
Time Factors
cardiovascular disease
dyslipidaemia
lipidomics
low carbohydrate diet
randomized trial
type 1 diabetes
Journal
Endocrinology, diabetes & metabolism
ISSN: 2398-9238
Titre abrégé: Endocrinol Diabetes Metab
Pays: England
ID NLM: 101732442
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
08
10
2020
accepted:
14
11
2020
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Lipid metabolism might be compromised in type 1 diabetes, and the understanding of lipid physiology is critically important. This study aimed to compare the change in plasma lipid concentrations during carbohydrate dietary changes in individuals with type 1 diabetes and identify links to early-stage dyslipidaemia. We hypothesized that (1) the lipidomic profiles after ingesting low or high carbohydrate diet for 12 weeks would be different; and (2) specific annotated lipid species could have significant associations with metabolic outcomes. Ten adults with type 1 diabetes (mean ± SD: age 43.6 ± 13.8 years, diabetes duration 24.5 ± 13.4 years, BMI 24.9 ± 2.1 kg/m In total, 289 lipid species were identified from 14 major lipid classes. Comparing the two diets, 11 lipid species belonging to sphingomyelins, phosphatidylcholines and LPC(O-16:0) were changed. All the 11 lipid species were significantly elevated during low carbohydrate diet. Two lipid species were most differentiated between diets, namely SM(d36:1) (β ± SE: 1.44 ± 0.28, Lipidome-wide outcome analysis of a randomized crossover trial of individuals with type 1 diabetes following a low carbohydrate diet showed an increase in sphingomyelins and phosphatidylcholines which are thought to reduce dyslipidaemia. The polyunsaturated phosphatidylcholine 35:4 was inversely associated with BMI and positively associated with HDL cholesterol (p < .001). Results from this study warrant for more investigation on the long-term effect of single lipid species in type 1 diabetes.
Identifiants
pubmed: 33855215
doi: 10.1002/edm2.213
pmc: PMC8029500
doi:
Substances chimiques
Cholesterol, HDL
0
Phosphatidylcholines
0
Sphingomyelins
0
polyene phosphatidylcholine
0
Banques de données
ClinicalTrials.gov
['NCT02888691']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00213Informations de copyright
© 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
None of the investigators has personal interests in the conduct or the outcomes of the study.
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