Sub millimetre flexible fibre probe for background and fluorescence free Raman spectroscopy.
Raman fibre probe
Raman spectroscopy
SERDS
hollow-core fibre
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
26
03
2021
received:
09
12
2020
accepted:
11
04
2021
pubmed:
16
4
2021
medline:
21
10
2021
entrez:
15
4
2021
Statut:
ppublish
Résumé
Using the shifted-excitation Raman difference spectroscopy technique and an optical fibre featuring a negative curvature excitation core and a coaxial ring of high numerical aperture collection cores, we have developed a portable, background and fluorescence free, endoscopic Raman probe. The probe consists of a single fibre with a diameter of less than 0.25 mm packaged in a sub-millimetre tubing, making it compatible with standard bronchoscopes. The Raman excitation light in the fibre is guided in air and therefore interacts little with silica, enabling an almost background free transmission of the excitation light. In addition, we used the shifted-excitation Raman difference spectroscopy technique and a tunable 785 nm laser to separate the fluorescence and the Raman spectrum from highly fluorescent samples, demonstrating the suitability of the probe for biomedical applications. Using this probe we also acquired fluorescence free human lung tissue data.
Identifiants
pubmed: 33855811
doi: 10.1002/jbio.202000488
doi:
Substances chimiques
Fluorescent Dyes
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202000488Subventions
Organisme : Cancer Research UK
ID : A24867
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R017794/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.
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