Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?
ACE2
COVID-19
cilia
corona virus
Journal
Physiological genomics
ISSN: 1531-2267
Titre abrégé: Physiol Genomics
Pays: United States
ID NLM: 9815683
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
16
4
2021
medline:
9
7
2021
entrez:
15
4
2021
Statut:
ppublish
Résumé
A worldwide coronavirus pandemic is in full swing and, at the time of writing, there are only few treatments that have been successful in clinical trials, but no effective antiviral treatment has been approved. Because of its lethality, it is important to understand the current strain's effects and mechanisms not only in the respiratory system but also in other affected organ systems as well. Past coronavirus outbreaks caused by SARS-CoV and MERS-CoV inflicted life-threatening acute kidney injuries (AKI) on their hosts leading to significant mortality rates, which went somewhat overlooked in the face of the severe respiratory effects. Recent evidence has emphasized renal involvement in SARS-CoV-2, stressing that kidneys are damaged in patients with COVID-19. The mechanism by which this virus inflicts AKI is still unclear, but evidence from other coronavirus strains may hold some clues. Two theories exist for the proposed mechanism of AKI:
Identifiants
pubmed: 33855870
doi: 10.1152/physiolgenomics.00015.2021
pmc: PMC8213509
doi:
Substances chimiques
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-258Subventions
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : R15HL140523
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : 3R15HL140523-01S1
Organisme : American Heart Association (AHA)
ID : 19PRE34430055
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : 3R15HL140523-01S3
Organisme : American Foundation for Pharmaceutical Education (AFPE)
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : 3R15HL140523-01S2
Organisme : NHLBI NIH HHS
ID : R15 HL140523
Pays : United States
Références
N Engl J Med. 2020 Aug 6;383(6):590-592
pubmed: 32402155
Eur Respir J. 1998 Oct;12(4):982-8
pubmed: 9817179
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731
pubmed: 32226290
Hypertension. 2019 Oct;74(4):817-825
pubmed: 31422694
Clin Exp Pharmacol Physiol. 2013 Feb;40(2):123-37
pubmed: 23181475
Transbound Emerg Dis. 2019 Mar;66(2):831-841
pubmed: 30520548
Cell Mol Life Sci. 2012 Sep;69(17):2967-77
pubmed: 22481441
J Virol. 2005 Dec;79(24):15511-24
pubmed: 16306622
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Curr Opin Cell Biol. 2016 Aug;41:109-16
pubmed: 27232950
Lancet Respir Med. 2020 Jul;8(7):687-695
pubmed: 32386571
Travel Med Infect Dis. 2020 Sep - Oct;37:101831
pubmed: 32750416
Antiviral Res. 2020 Jun;178:104792
pubmed: 32272173
Vet Res. 2018 Jul 3;49(1):55
pubmed: 29970183
Diagnostics (Basel). 2020 Dec 16;10(12):
pubmed: 33339422
N Engl J Med. 2020 Jun 4;382(23):2261-2264
pubmed: 32433861
Curr Opin Cell Biol. 2003 Feb;15(1):105-10
pubmed: 12517711
Clin Sci (Lond). 2020 Mar 13;134(5):543-545
pubmed: 32167153
J Racial Ethn Health Disparities. 2021 Dec;8(6):1356-1363
pubmed: 33565050
J Biol Chem. 2001 May 18;276(20):17132-9
pubmed: 11278314
Eur Respir J. 2001 Dec;18(6):965-70
pubmed: 11829103
Clin Cancer Res. 2015 Mar 15;21(6):1289-97
pubmed: 25593302
Kidney Int. 2020 Jun;97(6):1076-1082
pubmed: 32354637
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Crit Care. 2011 Feb 22;15(1):R66
pubmed: 21342489
Nat Commun. 2020 Oct 28;11(1):5453
pubmed: 33116139
J Virol Methods. 2009 Mar;156(1-2):19-26
pubmed: 19027037
J Cell Sci. 2010 May 15;123(Pt 10):1785-95
pubmed: 20427320
Respir Physiol Neurobiol. 2021 Jan;283:103548
pubmed: 32956843
J Cell Sci. 2020 Jul 8;133(13):
pubmed: 32503942
Sci Rep. 2018 Jun 27;8(1):9778
pubmed: 29950581
Int J Mol Sci. 2020 May 05;21(9):
pubmed: 32380787
Curr Med Chem. 2007;14(6):639-47
pubmed: 17346152
Cell Metab. 2005 Dec;2(6):373-84
pubmed: 16330323
Kidney Int. 2020 May;97(5):829-838
pubmed: 32247631
Nature. 2013 Mar 14;495(7440):251-4
pubmed: 23486063
J Pathol. 2017 Jan;241(2):294-309
pubmed: 27859258
Life Sci. 2020 Nov 1;260:118431
pubmed: 32946915
Curr Biol. 2014 Oct 6;24(19):R973-82
pubmed: 25291643
J Allergy Clin Immunol. 2003 Sep;112(3):518-24
pubmed: 13679810
J Am Coll Cardiol. 2020 May 12;75(18):2352-2371
pubmed: 32201335
Histopathology. 2018 Feb;72(3):516-524
pubmed: 28858401
Curr Opin Cell Biol. 2010 Aug;22(4):541-6
pubmed: 20399632
J Cell Biol. 2015 Mar 16;208(6):693-701
pubmed: 25753040
Intensive Care Med. 2020 Jun;46(6):1114-1116
pubmed: 32236644
Emerg Infect Dis. 2004 Jun;10(6):1030-7
pubmed: 15207054
SN Compr Clin Med. 2020 Jun 4;:1-3
pubmed: 32838138
Adv Virus Res. 2019;105:93-116
pubmed: 31522710
Front Cell Dev Biol. 2021 Feb 11;9:621318
pubmed: 33644059
Cell Res. 2008 Feb;18(2):290-301
pubmed: 18227861
Pulm Circ. 2018 Apr-Jun;8(2):2045894018764629
pubmed: 29480152
Andrology. 2019 Sep;7(5):588-602
pubmed: 31131532
Cells. 2019 Jul 29;8(8):
pubmed: 31362462
FASEB J. 2008 Aug;22(8):2880-7
pubmed: 18424768
Nat Commun. 2020 Dec 9;11(1):6317
pubmed: 33298944
Science. 2020 May 29;368(6494):1012-1015
pubmed: 32303590
Clin Immunol. 2020 Jun;215:108427
pubmed: 32325252
Front Biosci (Schol Ed). 2012 Jan 01;4:1088-98
pubmed: 22202111
J Virol. 2010 Nov;84(21):11255-63
pubmed: 20719951
Eye (Lond). 2020 Jul;34(7):1212-1219
pubmed: 32382146
Eur Respir J. 2020 May 14;55(5):
pubmed: 32269089
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):407-412
pubmed: 32335367
Biochem Biophys Res Commun. 2007 Nov 9;363(1):1-5
pubmed: 17825789
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
Virchows Arch. 1994;424(3):295-300
pubmed: 8186894
Kidney Int. 2020 Jul;98(1):209-218
pubmed: 32416116
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
Pathog Dis. 2020 Jun 1;78(4):
pubmed: 32633327
Virology. 2009 Jan 5;383(1):39-46
pubmed: 18986662
Drug Dev Res. 2020 Aug;81(5):537-540
pubmed: 32129518
PLoS One. 2007 May 02;2(5):e414
pubmed: 17476336
FEBS J. 2020 Sep;287(17):3664-3671
pubmed: 32428379
Am J Med Sci. 2020 Jul;360(1):5-34
pubmed: 32620220
J Pathol. 2001 Jan;193(1):134-40
pubmed: 11169526
Methods Mol Biol. 2015;1282:1-23
pubmed: 25720466
Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1454-F1462
pubmed: 32412303
Adv Virus Res. 2005;64:165-230
pubmed: 16139595
Nature. 1992 Jun 4;357(6377):420-2
pubmed: 1350662