Outcome of acute kidney injury: how to make a difference?

Acute kidney injury Chronic kidney disease Intensive care Long-term outcome

Journal

Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873

Informations de publication

Date de publication:
15 Apr 2021
Historique:
received: 30 07 2020
accepted: 03 04 2021
entrez: 15 4 2021
pubmed: 16 4 2021
medline: 16 4 2021
Statut: epublish

Résumé

Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervolemia, drug overdose), the occurrence of long-term complications and/or chronic comorbidities related to AKI has long been underestimated. The aim of this manuscript is to briefly review the short- and long-term consequences of AKI and discuss strategies likely to improve outcome of AKI. We reviewed the literature, focusing on the consequences of AKI in all its aspects and the management of AKI. We addressed the importance of clinical management for improving outcomes AKI. Finally, we have also proposed candidate future strategies and management perspectives. AKI must be considered as a systemic disease. Due to its short- and long-term impact, measures to prevent AKI and limit the consequences of AKI are expected to improve global outcomes of patients suffering from critical illnesses.

Sections du résumé

BACKGROUND BACKGROUND
Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervolemia, drug overdose), the occurrence of long-term complications and/or chronic comorbidities related to AKI has long been underestimated. The aim of this manuscript is to briefly review the short- and long-term consequences of AKI and discuss strategies likely to improve outcome of AKI.
MAIN BODY METHODS
We reviewed the literature, focusing on the consequences of AKI in all its aspects and the management of AKI. We addressed the importance of clinical management for improving outcomes AKI. Finally, we have also proposed candidate future strategies and management perspectives.
CONCLUSION CONCLUSIONS
AKI must be considered as a systemic disease. Due to its short- and long-term impact, measures to prevent AKI and limit the consequences of AKI are expected to improve global outcomes of patients suffering from critical illnesses.

Identifiants

pubmed: 33856581
doi: 10.1186/s13613-021-00849-x
pii: 10.1186/s13613-021-00849-x
pmc: PMC8050180
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

60

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Auteurs

Matthieu Jamme (M)

Service de Réanimation, Hôpital de Poissy, CHI Poissy Saint Germain, 10 rue du champ Gaillard, 78300, Poissy, France. matthieu.jamme@ght-yvelinesnord.fr.
INSERM UMR 1018, Equipe Epidémiologie clinique, CESP, Villejuif, France. matthieu.jamme@ght-yvelinesnord.fr.
Université Paris Saclay, UFR Simone Veil - Santé, Montigny-Le-Bretonneux, France. matthieu.jamme@ght-yvelinesnord.fr.

Matthieu Legrand (M)

Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA.

Guillaume Geri (G)

INSERM UMR 1018, Equipe Epidémiologie clinique, CESP, Villejuif, France.
Université Paris Saclay, UFR Simone Veil - Santé, Montigny-Le-Bretonneux, France.
Service de Médecine Intensive Réanimation, Hôpital Ambroise Paré, AP-HP, Boulogne Billancourt, France.

Classifications MeSH