ZW800-PEG: A Renal Clearable Zwitterionic Near-Infrared Fluorophore for Potential Clinical Translation.
minimal toxicity
photothermal therapy
renal clearance
serum stability
zwitterionic fluorophores
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
14 06 2021
14 06 2021
Historique:
revised:
30
03
2021
received:
21
02
2021
pubmed:
16
4
2021
medline:
1
9
2021
entrez:
15
4
2021
Statut:
ppublish
Résumé
Near-infrared (NIR) fluorescence imaging has advanced medical imaging and image-guided interventions during the past three decades. Despite tremendous advances in imaging devices, surprisingly only a few dyes are currently available in the clinic. Previous fluorophores, ZW800-1A and ZW800-1C, significantly improved the poor performance of the FDA-approved indocyanine green. However, ZW800-1A is not stable in serum and ZW800-1C induces severe stacking in aqueous media. To solve such dilemmas, ZW800-PEG was designed by introducing a flexible yet stable thiol PEG linker. ZW800-PEG shows high solubility in both aqueous and organic solvents, thus improving renal clearance with minimal binding to serum proteins during systemic circulation. The sulfide group on the meso position of the heptamethine core improves serum stability and physicochemical properties including the maximum emission wavelength shift to 800 nm, enabling the use of ZW800-PEG for image-guided interventions and augmenting photothermal therapy.
Identifiants
pubmed: 33857346
doi: 10.1002/anie.202102640
pmc: PMC8428668
mid: NIHMS1737746
doi:
Substances chimiques
Fluorescent Dyes
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13847-13852Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL143020
Pays : United States
Organisme : NIH HHS
ID : R01EB022230
Pays : United States
Organisme : National Research Foundation of Korea
ID : 2019M3D1A1078938
Organisme : NIBIB NIH HHS
ID : R01 EB022230
Pays : United States
Organisme : NIH HHS
ID : R01HL143020
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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