Mild magnetic nanoparticle hyperthermia promotes the disaggregation and microglia-mediated clearance of beta-amyloid plaques.
Beta-amyloid
Hyperthermia
Magnetic nanoparticles
Microglia
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
03
11
2020
accepted:
18
03
2021
pubmed:
16
4
2021
medline:
15
1
2022
entrez:
15
4
2021
Statut:
ppublish
Résumé
The formation of beta-amyloid (Aβ) plaques is a classical hallmark of Alzheimer's disease (AD) that is associated with the promotion of neuroinflammation and subsequent neurotoxicity. Given the limited therapeutic options for targeting and clearing Aβ plaques in AD, there is an urgent need to develop effective approaches to reduce plaque accumulation. The objective of this study was to validate mild magnetic nanoparticle (MNP) hyperthermia technology as a strategy to clear Aβ deposits and determine the impact on microglia functionality. Our results demonstrated that the heating of MNPs localized to Aβ aggregates upon exposure to high frequency alternating magnetic field (AMF) was sufficient to disrupt Aβ plaques, resulting in its fragmentation. Importantly, this could facilitate the phagocytic clearance of Aβ as well as attenuate pro-inflammatory responses by human microglial cells. Our results support the feasibility of mild MNP/AMF hyperthermia as a new strategy for reducing beta-amyloid burdens in Alzheimer's disease.
Identifiants
pubmed: 33857686
pii: S1549-9634(21)00040-X
doi: 10.1016/j.nano.2021.102397
pmc: PMC8217164
mid: NIHMS1693141
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102397Subventions
Organisme : NINR NIH HHS
ID : R01 NR015674
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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