Classical scrapie in small ruminants is caused by at least four different prion strains.
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
15 Apr 2021
15 Apr 2021
Historique:
received:
23
12
2020
accepted:
15
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
24
8
2021
Statut:
epublish
Résumé
The diversity of goat scrapie strains in Europe has recently been studied using bioassays in a wide collection of rodent models, resulting in the classification of classical scrapie into four different categories. However, the sole use of the first passage does not lead to isolate adaptation and identification of the strains involved and might therefore lead to misclassification of some scrapie isolates. Therefore, this work reports the complete transmission study of a wide collection of goat transmissible spongiform encephalopathy (TSE) isolates by intracranial inoculation in two transgenic mouse lines overexpressing either small ruminant (TgGoat-ARQ) or bovine (TgBov) PrP
Identifiants
pubmed: 33858518
doi: 10.1186/s13567-021-00929-7
pii: 10.1186/s13567-021-00929-7
pmc: PMC8048364
doi:
Substances chimiques
Prions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57Subventions
Organisme : EU
ID : FOOD-CT-2006-36353 [GoatBSE]
Organisme : EU
ID : FOOD-CT-2006-36353 [GoatBSE]
Organisme : EU
ID : 219235 ERA-NET EMIDA [GOAT-TSE-FREE]
Organisme : EU
ID : 219235 ERA-NET EMIDA [GOAT-TSE-FREE]
Organisme : EU
ID : 219235 ERA-NET EMIDA [GOAT-TSE-FREE]
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2009-11553-C02-02
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2016-78054-R (AEI/FEDER, UE)
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2016-78054-R (AEI/FEDER, UE)
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : BES-2010- 040922
Organisme : Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
ID : INIA-FPI-SGIT-2015-02
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