Long-term Clinical Outcomes of Repeat Salvage Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: A Case Series.
Nodal-recurrent prostate cancer
Oncological outcome
Salvage lymph node dissection
Journal
European urology focus
ISSN: 2405-4569
Titre abrégé: Eur Urol Focus
Pays: Netherlands
ID NLM: 101665661
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
29
11
2020
revised:
04
03
2021
accepted:
28
03
2021
pubmed:
17
4
2021
medline:
9
6
2022
entrez:
16
4
2021
Statut:
ppublish
Résumé
This case series highlights the role of repeat salvage lymph node dissection (sLND) for nodal-recurrent prostate cancer. We provide a descriptive analysis of ten patients who underwent sLND in a total of 23 surgeries (mean 2.3 sLNDs per patient) and their long-term follow-up (median of 158 mo after radical prostatectomy). A complete prostate-specific antigen response was observed in nine/23 cases (39.1%), and an incomplete response in 14 (60.9%). Analysis by anatomical location revealed a trend towards more distant metastases on repeat surgery, with only three in-field recurrences in patients with previously positive nodes. Repeat sLND can be surgically challenging, and major intraoperative complications were observed in three/23 cases (13.0%). Repeat sLND for patients with nodal-recurrent prostate cancer seems to be a feasible treatment option, albeit only in carefully selected patients. Nevertheless, it remains a highly experimental approach with unclear oncological benefit.
Identifiants
pubmed: 33858813
pii: S2405-4569(21)00104-8
doi: 10.1016/j.euf.2021.03.025
pii:
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-430Informations de copyright
Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.