Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
15 04 2021
15 04 2021
Historique:
received:
07
05
2020
accepted:
25
02
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-regulated and spreads along the future inactive X chromosome. Contextually, it recruits repressive histone and DNA modifiers that transcriptionally silence the X chromosome. Xist regulation is tightly coupled to differentiation and its expression is under the control of both pluripotency and epigenetic factors. Recent evidence has suggested that chromatin remodelers accumulate at the X Inactivation Center (XIC) and here we demonstrate a new role for Chd8 in Xist regulation in differentiating ES cells, linked to its control and prevention of spurious transcription factor interactions occurring within Xist regulatory regions. Our findings have a broader relevance, in the context of complex, developmentally-regulated gene expression.
Identifiants
pubmed: 33859315
doi: 10.1038/s42003-021-01945-1
pii: 10.1038/s42003-021-01945-1
pmc: PMC8050208
doi:
Substances chimiques
DNA-Binding Proteins
0
RNA, Long Noncoding
0
duplin protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
485Subventions
Organisme : Medical Research Council
Pays : United Kingdom
Références
Genome Res. 2017 Jul;27(7):1139-1152
pubmed: 28536180
Nature. 2012 Apr 29;485(7398):386-90
pubmed: 22596162
Nat Rev Mol Cell Biol. 2017 Jul;18(7):407-422
pubmed: 28512350
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
Mol Cell Biol. 2001 Dec;21(24):8512-20
pubmed: 11713286
Chromosoma. 2016 Mar;125(1):41-50
pubmed: 26198462
Nature. 2016 Feb 4;530(7588):113-6
pubmed: 26814966
Genes Dev. 2005 Jun 15;19(12):1474-84
pubmed: 15964997
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Nat Struct Mol Biol. 2019 May;26(5):331-334
pubmed: 31061525
Nature. 2016 Sep 29;537(7622):675-679
pubmed: 27602517
Mol Cell. 2014 Mar 20;53(6):965-78
pubmed: 24613346
Science. 2017 Jun 9;356(6342):1081-1084
pubmed: 28596365
Nat Methods. 2016 Dec 29;14(1):5-6
pubmed: 28032625
Nat Commun. 2014 Sep 11;5:4878
pubmed: 25209548
Bioinformatics. 2002;18 Suppl 1:S96-104
pubmed: 12169536
Mol Cell. 2017 Dec 7;68(5):955-969.e10
pubmed: 29220657
Sci Rep. 2016 Nov 18;6:37324
pubmed: 27857184
Mol Cell. 2018 May 3;70(3):462-472.e8
pubmed: 29706539
Genes Dev. 2006 Aug 15;20(16):2223-37
pubmed: 16912274
Stem Cell Rev Rep. 2015 Oct;11(5):699-705
pubmed: 26198263
Genome Biol. 2014;15(12):550
pubmed: 25516281
Mol Cell Biol. 2016 Oct 13;36(21):2656-2667
pubmed: 27528619
Nat Cell Biol. 2006 May;8(5):532-8
pubmed: 16570078
Nat Commun. 2015 Mar 10;6:6404
pubmed: 25752243
Nucleic Acids Res. 2014 Feb;42(4):2185-96
pubmed: 24265227
Mamm Genome. 2005 Jun;16(6):391-404
pubmed: 16075366
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Mol Cell. 2006 Mar 3;21(5):617-28
pubmed: 16507360
Cell. 2013 Jun 20;153(7):1537-51
pubmed: 23791181
Cell Rep. 2015 Jul 28;12(4):562-72
pubmed: 26190105
Curr Opin Genet Dev. 2013 Apr;23(2):109-15
pubmed: 23465885
Curr Opin Cell Biol. 2004 Jun;16(3):247-55
pubmed: 15145348
Nat Rev Genet. 2011 Jun;12(6):429-42
pubmed: 21587299
Gene. 2001 Mar 21;266(1-2):131-7
pubmed: 11290427
Cell. 2017 May 18;169(5):930-944.e22
pubmed: 28525758
Curr Opin Cell Biol. 2012 Jun;24(3):397-404
pubmed: 22425180
Transl Psychiatry. 2015 May 19;5:e568
pubmed: 25989142
Nat Neurosci. 2016 Nov;19(11):1477-1488
pubmed: 27694995
Nat Neurosci. 2017 Aug;20(8):1062-1073
pubmed: 28671691
Nat Commun. 2019 May 16;10(1):2192
pubmed: 31097699
Mol Cell Biol. 2004 Oct;24(19):8386-94
pubmed: 15367660
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Science. 2014 Oct 3;346(6205):1255784
pubmed: 25278616
Mol Autism. 2018 Dec 19;9:65
pubmed: 30574290
Genome Biol. 2016 Aug 01;17(1):167
pubmed: 27480531
Nucleic Acids Res. 2018 Jan 4;46(D1):D762-D769
pubmed: 29106570
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Semin Cell Dev Biol. 2016 Aug;56:19-34
pubmed: 27072488
Cell. 2013 Aug 1;154(3):490-503
pubmed: 23911317
Cell. 2012 Apr 27;149(3):590-604
pubmed: 22541430
Cell. 2010 Oct 29;143(3):390-403
pubmed: 21029862
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nature. 2010 Jan 28;463(7280):474-84
pubmed: 20110991
Elife. 2012 Dec 18;1:e00205
pubmed: 23256043
Dev Cell. 2007 Jan;12(1):57-71
pubmed: 17199041
Mol Cell Biol. 2012 Jan;32(2):501-12
pubmed: 22083958
Open Biol. 2020 Sep;10(9):200126
pubmed: 32898472
Nat Neurosci. 2016 Oct 26;19(11):1430-1432
pubmed: 27786184
Nat Med. 2018 Jun;24(6):758-769
pubmed: 29785026
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4468-77
pubmed: 25294932
Front Mol Biosci. 2017 Dec 19;4:90
pubmed: 29302591
PLoS Genet. 2015 Apr 20;11(4):e1005174
pubmed: 25894978
Hum Genet. 2011 Aug;130(2):223-36
pubmed: 21626138
J Cell Physiol. 2006 Oct;209(1):162-71
pubmed: 16810678
Nat Methods. 2017 Oct;14(10):959-962
pubmed: 28846090
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Genome Biol. 2015 Aug 15;16:166
pubmed: 26282267
Hum Mol Genet. 2011 Feb 15;20(4):705-18
pubmed: 21118898
Nature. 2010 Nov 18;468(7322):457-60
pubmed: 21085182
Curr Opin Cell Biol. 2017 Jun;46:54-61
pubmed: 28236732
J Biol Chem. 2017 Jul 14;292(28):11927-11936
pubmed: 28533432
Science. 2008 Sep 19;321(5896):1693-5
pubmed: 18802003
Nat Cell Biol. 2019 May;21(5):568-578
pubmed: 31036938
Epigenetics Chromatin. 2009 Jul 20;2(1):8
pubmed: 19615107
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
pubmed: 18448678
Hum Mol Genet. 2006 Apr 1;15(7):1123-32
pubmed: 16500999
Genes Dev. 2006 Oct 15;20(20):2787-92
pubmed: 17043308
Arch Biochem Biophys. 2013 Jun;534(1-2):20-6
pubmed: 23031499
Genome Res. 2012 Oct;22(10):1864-76
pubmed: 22948768
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2235-40
pubmed: 24469834