Predicting ASD Diagnosis in Children with Synthetic and Image-based Eye Gaze Data.
Autism Spectrum Disorders
Deep Learning
Eye Gaze Data
Journal
Signal processing. Image communication
ISSN: 0923-5965
Titre abrégé: Signal Process Image Commun
Pays: Netherlands
ID NLM: 101668816
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
ppublish
Résumé
As early intervention is highly effective for young children with autism spectrum disorder (ASD), it is imperative to make accurate diagnosis as early as possible. ASD has often been associated with atypical visual attention and eye gaze data can be collected at a very early age. An automatic screening tool based on eye gaze data that could identify ASD risk offers the opportunity for intervention before the full set of symptoms is present. In this paper, we propose two machine learning methods, synthetic saccade approach and image based approach, to automatically classify ASD given children's eye gaze data collected from free-viewing tasks of natural images. The first approach uses a generative model of synthetic saccade patterns to represent the baseline scan-path from a typical non-ASD individual and combines it with the real scan-path as well as other auxiliary data as inputs to a deep learning classifier. The second approach adopts a more holistic image-based approach by feeding the input image and a sequence of fixation maps into a convolutional or recurrent neural network. Using a publicly-accessible collection of children's gaze data, our experiments indicate that the ASD prediction accuracy reaches 67.23% accuracy on the validation dataset and 62.13% accuracy on the test dataset.
Identifiants
pubmed: 33859457
doi: 10.1016/j.image.2021.116198
pmc: PMC8043618
mid: NIHMS1680140
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH121344
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
J Autism Dev Disord. 2002 Apr;32(2):69-75
pubmed: 12058845
Neuropsychologia. 2008 Sep;46(11):2855-60
pubmed: 18561959
Neuron. 2015 Nov 4;88(3):604-16
pubmed: 26593094
J Am Acad Child Adolesc Psychiatry. 2017 Apr;56(4):313-320
pubmed: 28335875
Neural Comput. 1997 Nov 15;9(8):1735-80
pubmed: 9377276
Nature. 2013 Dec 19;504(7480):427-31
pubmed: 24196715
J Child Psychol Psychiatry. 2014;55(2):162-71
pubmed: 24117668
MMWR Surveill Summ. 2018 Apr 27;67(6):1-23
pubmed: 29701730
J Exp Child Psychol. 2015 Mar;131:38-55
pubmed: 25514785
J Autism Dev Disord. 1999 Jun;29(3):213-24
pubmed: 10425584
J Autism Dev Disord. 2019 Jan;49(1):209-215
pubmed: 30097760
J Laryngol Otol. 1988 May;102(5):435-9
pubmed: 3397639
J Autism Dev Disord. 2018 Jul;48(7):2577-2584
pubmed: 29453707
IEEE Trans Image Process. 2018 Jun 29;:
pubmed: 29994710
Nat Rev Neurosci. 2001 Mar;2(3):194-203
pubmed: 11256080
Biol Psychiatry. 2013 Aug 1;74(3):189-94
pubmed: 23374640
J Child Psychol Psychiatry. 2003 Feb;44(2):274-84
pubmed: 12587863
J Autism Dev Disord. 2004 Oct;34(5):473-93
pubmed: 15628603
Neurosci Biobehav Rev. 2014 Nov;47:559-77
pubmed: 25454358
Front Neurosci. 2016 Dec 23;10:586
pubmed: 28066169
J Abnorm Psychol. 2016 Apr;125(3):399-411
pubmed: 26915060