A Phase II Trial of Melphalan Based Reduced-Intensity Conditioning for Transplantation of T-Replete HLA-Haploidentical Peripheral Blood Stem Cells with Posttransplant Cyclophosphamide in Patients with Hematologic Malignancies.
Journal
Advances in hematology
ISSN: 1687-9104
Titre abrégé: Adv Hematol
Pays: United States
ID NLM: 101504271
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
08
2020
revised:
11
02
2021
accepted:
08
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
epublish
Résumé
T-replete haploidentical donor transplants using posttransplant cyclophosphamide (haplo) have greatly expanded donor availability and are increasingly utilized. Haplo were originally performed using truly nonmyeloablative conditioning and a bone marrow graft. We have also developed myeloablative conditioning and peripheral blood stem cell (PBSC) grafts for use with haplo. However, some patients may not tolerate myeloablative conditioning but may still benefit from a more dose-intensified preparative regimen to control malignancy and diminish graft rejection. To this end, we enrolled 25 patients on a prospective phase II trial utilizing a regimen of fludarabine 30 mg/m
Identifiants
pubmed: 33859695
doi: 10.1155/2021/8868142
pmc: PMC8009703
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8868142Informations de copyright
Copyright © 2021 Melhem M. Solh et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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