Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice.
ADAMTS-4
ADATS-5
IL-6
MMP-12
STR/Ort
TMJ
elastin
Journal
Biomedical reports
ISSN: 2049-9434
Titre abrégé: Biomed Rep
Pays: England
ID NLM: 101613227
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
26
12
2020
accepted:
17
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
ppublish
Résumé
Temporomandibular joint dysfunction (TMJD) is characterised by clinical symptoms involving both the masticatory muscles and the temporomandibular joint (TMJ). Disc internal derangement and osteoarthritis (OA) are the most common forms of TMJD. Currently, the molecular process associated with degenerative changes in the TMJ is unclear. Our previous study showed that elastin-digested peptides act on human TMJ synovial cells and lead to upregulation of interleukin-6 (IL-6) and metalloelastase-12 (MMP-12; an elastin-degrading enzyme)
Identifiants
pubmed: 33859822
doi: 10.3892/br.2021.1427
pii: BR-0-0-01427
pmc: PMC8042671
doi:
Types de publication
Journal Article
Langues
eng
Pagination
51Subventions
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Informations de copyright
Copyright: © Yamashita-Futani et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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