Flexible and Stretchable PEDOT-Embedded Hybrid Substrates for Bioengineering and Sensory Applications.

cardiac tissue engineering electrochemical polymerization electrospinning flexible electronics poly(3,4-ethylene dioxythiophene) stretchable

Journal

ChemNanoMat : chemistry of nanomaterials for energy, biology and more
ISSN: 2199-692X
Titre abrégé: ChemNanoMat
Pays: Germany
ID NLM: 101693711

Informations de publication

Date de publication:
Jun 2019
Historique:
entrez: 16 4 2021
pubmed: 1 6 2019
medline: 1 6 2019
Statut: ppublish

Résumé

Herein, we introduce a flexible, biocompatible, robust and conductive electrospun fiber mat as a substrate for flexible and stretchable electronic devices for various biomedical applications. To impart the electrospun fiber mats with electrical conductivity, poly(3,4-ethylenedioxythiophene) (PEDOT), a conductive polymer, was interpenetrated into nitrile butadiene rubber (NBR) and poly(ethylene glycol) dimethacrylate (PEGDM) crosslinked electrospun fiber mats. The mats were fabricated with tunable fiber orientation, random and aligned, and displayed elastomeric mechanical properties and high conductivity. In addition, bending the mats caused a reversible change in their resistance. The cytotoxicity studies confirmed that the elastomeric and conductive electrospun fiber mats support cardiac cell growth, and thus are adaptable to a wide range of applications, including tissue engineering, implantable sensors and wearable bioelectronics.

Identifiants

DOI: 10.1002/cnma.201900146 PMID: 33859923 PMC: PMC8045745
pubmed: 33859923
doi: 10.1002/cnma.201900146
pmc: PMC8045745
mid: NIHMS1033979
doi:

Types de publication

Journal Article

Langues

eng

Pagination

729-737

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR074234
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB026824
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest The authors declare no conflict of interest.

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Auteurs

Afsoon Fallahi (A)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Serena Mandla (S)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
S. Mandla, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Thomas Kerr-Phillip (T)

Dr. T. Kerr-Phillip, Prof. J. Travas-Sejdic, Polymer Electronics Research Centre (PERC), School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Dr. T. Kerr-Phillip, Prof. J. Travas-Sejdic, The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand.

Jungmok Seo (J)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Prof. J. Seo, Centre for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, 14 Hwarang-ro, Seongbuk-gu, Seoul, 02792, Republic of Korea.

Raquel O Rodrigues (RO)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
R. O. Rodrigues, Laboratory of Separation and Reaction Engineering, Laboratory of Catalysis and Materials (LSRE-LCM), Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.

Yasamin A Jodat (YA)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Y. A. Jodat, Department of Mechanical Engineering, Stevens Institute of Technology, New Jersey, USA.

Roya Samanipour (R)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dr. R. Samanipour, School of Engineering, University of British Columbia, Okanagan, BC, Canada.

Mohammad Asif Hussain (MA)

Prof. M. A. Hussain, Department of Electrical and Computer Engineering, Faculty of Engineering, King Abdulaziz University, P.O. Box 80204, Jeddah 21589, Saudi Arabia.

Chang Kee Lee (CK)

Dr. C. K. Lee, Korea Packaging Center, Korea Institute of Industrial Technology, Bucheon, Republic of Korea.

Hojae Bae (H)

Prof. H. Bae, Prof. A. Khademhosseini, KU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.

Ali Khademhosseini (A)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Prof. H. Bae, Prof. A. Khademhosseini, KU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Prof. A. Khademhosseini, Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Prof. A. Khademhosseini, Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Prof. A. Khademhosseini, California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA 90095, USA.
Prof. A. Khademhosseini, Centre for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California - Los Angeles, Los Angeles, CA 90095, USA.
ORCID: 0000-0002-2692-1524

Jadranka Travas-Sejdic (J)

Dr. T. Kerr-Phillip, Prof. J. Travas-Sejdic, Polymer Electronics Research Centre (PERC), School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Dr. T. Kerr-Phillip, Prof. J. Travas-Sejdic, The MacDiarmid Institute for Advanced Materials and Nanotechnology New Zealand.
ORCID: 0000-0002-1205-3770

Su Ryon Shin (SR)

Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Office: (617) 768-8320,.
Dr. A. Fallahi, S. Mandla, Prof. J. Seo, R. O. Rodrigues, Y. A. Jodat, Dr. R. Samanipour, Prof. A. Khademhosseini, Dr. S. R. Shin, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-0864-6482

Classifications MeSH