Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex.
Alzheimer's disease
amyloid
integrative gene network
neurogranin
perirhinal cortex
synapse
tau
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
07
2020
revised:
29
01
2021
accepted:
10
02
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
epublish
Résumé
Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive. Using a large-scale transcriptomic dataset, we analyzed the neurogranin-centered integrative gene network and assessed the correlation of neurogranin ( We find that the genes positively correlated with Transcriptional regulation of the gene encoding for synaptic protein is involved in selective synaptic damage in AD. Identifying the genes associated with synaptic damage pathways in AD may provide targets for intervention.
Identifiants
pubmed: 33860070
doi: 10.1002/trc2.12162
pii: TRC212162
pmc: PMC8033412
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12162Subventions
Organisme : NIA NIH HHS
ID : R01 AG072520
Pays : United States
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
Henrik Zetterberg has served on scientific advisory boards for Eisai, Denali, Roche Diagnostics, Wave, Samumed, Siemens Healthineers, Pinteon Therapeutics, Nervgen, AZTherapies, and CogRx; has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure, and Biogen; and is a co‐founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). Kaj Blennow has served as a consultant, on advisory boards, or on data monitoring committees for Abcam, Axon, Biogen, Julius Clinical, Lilly, MagQu, Novartis, Roche Diagnostics, and Siemens Healthineers; and is a co‐founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). MMc has served on a scientific advisory board for Novartis Pharmaceuticals in the area of multiple sclerosis research.
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