Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
10
08
2020
revised:
30
10
2020
accepted:
22
11
2020
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
epublish
Résumé
Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [
Identifiants
pubmed: 33860121
doi: 10.1002/hep4.1660
pii: 02009842-202104000-00010
pmc: PMC8034574
doi:
Substances chimiques
Bile Acids and Salts
0
Organic Anion Transporters
0
SLCO1A2 protein, human
0
Solute Carrier Organic Anion Transporter Family Member 1B3
0
Types de publication
Journal Article
Langues
eng
Pagination
629-633Informations de copyright
© 2020 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.
Références
van de Steeg E, Stránecký V, Hartmannová H, Nosková L, Hřebíček M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012;122:519‐528.
Kagawa T, Oka A, Kobayashi Y, Hiasa Y, Kitamura T, Sakugawa H, et al. Recessive inheritance of population‐specific intronic LINE‐1 insertion causes a rotor syndrome phenotype. Hum Mutat 2015;36:327‐332.
Muto A, Takei H, Unna A, Murai T, Kurosawa T, Ogawa S, et al. Detection Δ 4 ‐3‐oxo‐steroid 5β‐reductase deficiency by LC‐ESI‐MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci 2012;900:24‐31.
Kagawa T, Adachi Y, Hashimonto N, Mitsui H, Ohashi T, Yoneda M, et al. Loss of organic anion transporting polypeptide 1B3 function causes marked delay indocyanine green clearance without any clinical symptoms. Hepatology 2017;65:1065‐1068.
Trottier J, Perreault M, Rudkowaka I, Levy C, Dallalre‐Theroux A, Verreault M, et al. Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate. Clin Pharmacol Ther 2013;94:533‐543.
Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, et al. Synthesis, physicochemical properties, and biological activity of bile acids 3‐glucuronides: novel insights into bile acid signalling and detoxification. Eur J Med Chem 2018;144:349‐358.
Meng LJ, Wang P, Wolkoff AW, Kim RB, Tirona RG, Hofmann AF, et al. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology 2002;35:1031‐1040.