Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
09 Apr 2021
09 Apr 2021
Historique:
received:
04
02
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
17
4
2021
Statut:
epublish
Résumé
The CaSR is a class C G protein-coupled receptor (GPCR) that acts as a multimodal chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic target in hyperparathyroidism and has emerged as a putative target in several other diseases. These include hyper- and hypocalcaemia caused either by mutations in the
Identifiants
pubmed: 33860192
doi: 10.1021/acsptsci.1c00046
pmc: PMC8033781
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
666-679Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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