Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans.
Aromatic or methionine–aromatic interaction
Collagen binding
Interaction surface
Mutations
Super motif
Journal
Journal of cell communication and signaling
ISSN: 1873-9601
Titre abrégé: J Cell Commun Signal
Pays: Netherlands
ID NLM: 101308338
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
13
02
2021
accepted:
25
03
2021
pubmed:
17
4
2021
medline:
17
4
2021
entrez:
16
4
2021
Statut:
ppublish
Résumé
Small leucine rich repeat proteoglycans (SLRPs) are a group of active components of the extracellular matrix in all tissues. SLRPs bind to collagens and regulate collagen fibril growth and fibril organization. SLRPs also interact with various cytokines and extracellular compounds, which lead to various biological functions such cell adhesion and signaling, proliferation, and differentiation. Mutations in SLRP genes are associated with human diseases. Now crystal structures of five SLRPs are available. We describe some features of amino acid sequence and structures of SLRPs. We also review ligand interactions and then discuss the interaction surfaces. Furthermore, we map mutations associated with human diseases and discuss possible effects on structures by the mutations.
Identifiants
pubmed: 33860400
doi: 10.1007/s12079-021-00616-4
pii: 10.1007/s12079-021-00616-4
pmc: PMC8642563
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
519-531Informations de copyright
© 2021. The International CCN Society.
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