Polysulfates Block SARS-CoV-2 Uptake through Electrostatic Interactions*.
A549 Cells
Animals
Antiviral Agents
/ chemistry
Chlorocebus aethiops
Heparin
/ chemistry
Humans
Molecular Dynamics Simulation
Pentosan Sulfuric Polyester
/ chemistry
Polymers
/ chemistry
Protein Binding
SARS-CoV-2
/ chemistry
Spike Glycoprotein, Coronavirus
/ chemistry
Static Electricity
Vero Cells
Virus Internalization
/ drug effects
SARS-CoV-2
electrostatic interactions
inhibition
polysulfates
virus binding
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
12 07 2021
12 07 2021
Historique:
revised:
29
03
2021
received:
23
02
2021
pubmed:
17
4
2021
medline:
14
7
2021
entrez:
16
4
2021
Statut:
ppublish
Résumé
Here we report that negatively charged polysulfates can bind to the spike protein of SARS-CoV-2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS-CoV-2 by heparin, pentosan sulfate, linear polyglycerol sulfate (LPGS) and hyperbranched polyglycerol sulfate (HPGS). Highly sulfated LPGS is the optimal inhibitor, with an IC
Identifiants
pubmed: 33860605
doi: 10.1002/anie.202102717
pmc: PMC8250366
doi:
Substances chimiques
Antiviral Agents
0
Polymers
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Pentosan Sulfuric Polyester
37300-21-3
Heparin
9005-49-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15870-15878Subventions
Organisme : Berlin University Alliance
Organisme : Freie Universität Berlin
ID : Focus Area NanoScale
Organisme : Deutsche Forschungsgemeinschaft
ID : BioSupraMol
Organisme : Deutsche Forschungsgemeinschaft
ID : IRTG-2262
Organisme : Bundesministerium für Bildung und Forschung
Organisme : Max-Planck-Gesellschaft
ID : Max-Planck MaxWater initiative
Informations de copyright
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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