Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic.
H7N9
HPAIV
clinical features
epidemiology
hemagglutinin
immunity
pathogenesis
vaccine
Journal
Frontiers of medicine
ISSN: 2095-0225
Titre abrégé: Front Med
Pays: China
ID NLM: 101549428
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
15
02
2020
accepted:
08
07
2020
pubmed:
17
4
2021
medline:
21
8
2021
entrez:
16
4
2021
Statut:
ppublish
Résumé
The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry markets. It has caused infections in humans in China since 2013. Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017. H7N9 with low-pathogenicity dominated in the first four waves, whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave, causing wide concern. Specialists and officials from China and other countries responded quickly, controlled the epidemic well thus far, and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts. Here, we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease. It was summarized and discussed from the perspectives of molecular epidemiology, clinical features, virulence and pathogenesis, receptor binding, T-cell responses, monoclonal antibody development, vaccine development, and disease burden. These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses, such as SARS-CoV-2.
Identifiants
pubmed: 33860875
doi: 10.1007/s11684-020-0814-5
pii: 10.1007/s11684-020-0814-5
pmc: PMC8190734
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-527Informations de copyright
© 2021. The Author(s).
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