Derivation of an HIV Risk Score for African Women Who Engage in Sex Work.


Journal

AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133

Informations de publication

Date de publication:
Oct 2021
Historique:
accepted: 13 03 2021
pubmed: 17 4 2021
medline: 8 9 2021
entrez: 16 4 2021
Statut: ppublish

Résumé

No tool exists to stratify HIV risk in contemporary African female sex worker (FSW) populations. Data from a cohort of HIV-negative FSWs in Mombasa, Kenya from 2010 to 2017 were used to conduct a survival analysis assessing predictors of HIV infection. Stepwise regression was used to construct a multivariable model that formed the basis for the score. Seventeen HIV infections occurred over 1247 person-years of follow-up contributed by 670 women. Using depot medroxyprogesterone acetate (DMPA), having a curable sexually transmitted infection (STI), and being married contributed points to the score. HIV incidence was 0.85/100 person-years in a lower-risk group and 3.10/100 person-years in a higher-risk group. In a cohort with overall HIV incidence < 1.50/100 person-years, this risk score identified a subgroup of FSWs with HIV incidence > 3.00/100 person-years, which is the threshold used by the World Health Organization for initiating pre-exposure prophylaxis (PrEP). If validated in an external population, this tool could be useful for targeted PrEP promotion among higher-risk FSWs.

Identifiants

pubmed: 33861378
doi: 10.1007/s10461-021-03235-7
pii: 10.1007/s10461-021-03235-7
pmc: PMC8763393
mid: NIHMS1768821
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3292-3302

Subventions

Organisme : NICHD NIH HHS
ID : K24 HD088229
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : K24 HD88229
Organisme : NIAID NIH HHS
ID : R37 AI038518
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : R37 AI38518/HD103571
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD103571
Pays : United States

Informations de copyright

© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Alexandra C Willcox (AC)

University of Washington School of Medicine, Seattle, WA, USA.
Medical Scientist Training Program, University of Washington, Seattle, WA, USA.

Barbra A Richardson (BA)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
Department of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Juma Shafi (J)

Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.

Emmanuel Kabare (E)

Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.

John Kinuthia (J)

Kenyatta National Hospital, University of Nairobi, Nairobi, Kenya.

Walter Jaoko (W)

Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.

Kishorchandra Mandaliya (K)

Department of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA.

Julie Overbaugh (J)

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

R Scott McClelland (RS)

Department of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA. mcclell@uw.edu.
Department of Medicine, University of Washington, Seattle, WA, USA. mcclell@uw.edu.
Department of Epidemiology, University of Washington, Seattle, WA, USA. mcclell@uw.edu.
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya. mcclell@uw.edu.

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