Podocyte Sphingolipid Signaling in Nephrotic Syndrome.
Sphingolipid; Acid ceramidase; Sphingomyelin-like phosphodiesterase 3b; Podocyte; Nephrotic syndrome
Journal
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
ISSN: 1421-9778
Titre abrégé: Cell Physiol Biochem
Pays: Germany
ID NLM: 9113221
Informations de publication
Date de publication:
17 Apr 2021
17 Apr 2021
Historique:
accepted:
29
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
25
8
2021
Statut:
ppublish
Résumé
Podocytes play a vital role in the pathogenesis of nephrotic syndrome (NS), which is clinically characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia, and peripheral edema. The pathogenesis of NS has evolved through several hypotheses ranging from immune dysregulation theory and increased glomerular permeability theory to the current concept of podocytopathy. Podocytopathy is characterized by dysfunction or depletion of podocytes, which may be caused by unknown permeability factor, genetic disorders, drugs, infections, systemic disorders, and hyperfiltration. Over the last two decades, numerous studies have been done to explore the molecular mechanisms of podocyte injuries or NS and to develop the novel therapeutic strategies targeting podocytopathy for treatment of NS. Recent studies have shown that normal sphingolipid metabolism is essential for structural and functional integrity of podocytes. As a basic component of the plasma membrane, sphingolipids not only support the assembly of signaling molecules and interaction of receptors and effectors, but also mediate various cellular activities, such as apoptosis, proliferation, stress responses, necrosis, inflammation, autophagy, senescence, and differentiation. This review briefly summarizes current evidence demonstrating the regulation of sphingolipid metabolism in podocytes and the canonical or noncanonical roles of podocyte sphingolipid signaling in the pathogenesis of NS and associated therapeutic strategies.
Identifiants
pubmed: 33861526
doi: 10.33594/000000356
pmc: PMC8193717
mid: NIHMS1711229
doi:
Substances chimiques
Sphingolipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-34Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK054927
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120491
Pays : United States
Organisme : NIH (National Institutes of Health)
ID : DK054927, DK120491
Pays : United States
Informations de copyright
© Copyright by the Author(s). Published by Cell Physiol Biochem Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Rep Biochem Mol Biol. 2018 Oct;7(1):1-8
pubmed: 30324111
Nature. 1993 Oct 7;365(6446):557-60
pubmed: 8413613
J Am Soc Nephrol. 2015 Jan;26(1):133-47
pubmed: 24925721
Cell Physiol Biochem. 2015;35(5):1773-86
pubmed: 25832774
Pediatr Nephrol. 2002 Aug;17(8):673-7
pubmed: 12185480
Adv Biol Regul. 2018 Dec;70:31-39
pubmed: 30455062
PLoS One. 2013 May 17;8(5):e63506
pubmed: 23691056
J Am Soc Nephrol. 2018 Sep;29(9):2348-2361
pubmed: 30143558
J Cell Biol. 1998 Jul 13;142(1):229-40
pubmed: 9660876
Transplant Proc. 2004 Mar;36(2 Suppl):549S-553S
pubmed: 15041404
Nat Rev Dis Primers. 2020 Aug 13;6(1):68
pubmed: 32792490
Am Fam Physician. 2009 Nov 15;80(10):1129-34
pubmed: 19904897
Scand J Clin Lab Invest. 1971 Jun;27(4):393-405
pubmed: 5109101
J Am Soc Nephrol. 2002 Jun;13 Suppl 2:S134-8
pubmed: 12068025
Biochem J. 2012 Feb 1;441(3):789-802
pubmed: 22248339
Pediatr Nephrol. 2012 Feb;27(2):317-20
pubmed: 22076591
Kidney Int. 2011 Dec;80(12):1315-27
pubmed: 21849969
Gene. 2014 Feb 15;536(1):97-104
pubmed: 24334116
Blood. 2006 Feb 1;107(3):1070-7
pubmed: 16223774
Biochimie. 2010 Jun;92(6):707-15
pubmed: 20156522
Immunol Rev. 2010 Sep;237(1):264-83
pubmed: 20727041
Kidney Int. 2002 Dec;62(6):1933-46
pubmed: 12427118
Adv Exp Med Biol. 2010;688:156-64
pubmed: 20919653
Hum Mutat. 2017 Apr;38(4):365-372
pubmed: 28181337
Front Endocrinol (Lausanne). 2014 Jul 30;5:127
pubmed: 25126087
J Am Soc Nephrol. 2018 Jun;29(6):1662-1678
pubmed: 29720549
Pediatr Nephrol. 2019 Jan;34(1):11-30
pubmed: 29181712
Pharmacol Rev. 2008 Jun;60(2):181-95
pubmed: 18552276
J Transl Med. 2019 Aug 13;17(1):264
pubmed: 31409386
J Biol Chem. 2006 Mar 31;281(13):8518-27
pubmed: 16415355
Kidney Int Rep. 2019 Aug 07;4(12):1763-1769
pubmed: 31844815
Toxicol Pathol. 2015 Jul;43(5):694-703
pubmed: 25630683
Pediatric Health Med Ther. 2017 Apr 11;8:29-37
pubmed: 29388620
Int J Mol Sci. 2020 Feb 25;21(5):
pubmed: 32106480
Am J Physiol Renal Physiol. 2006 Jun;290(6):F1516-24
pubmed: 16403835
Trends Cell Biol. 2012 Jan;22(1):50-60
pubmed: 22001186
Am J Nephrol. 2018;47 Suppl 1:14-29
pubmed: 29852493
Am J Nephrol. 2010;31(4):353-62
pubmed: 20234131
Am J Kidney Dis. 2020 Jun;75(6):955-964
pubmed: 32331832
Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C481-C491
pubmed: 31268777
Nephrol Dial Transplant. 2015 Mar;30(3):375-84
pubmed: 24589721
Clin Chem. 2013 Mar;59(3):547-56
pubmed: 23237761
J Am Soc Nephrol. 2017 Sep;28(9):2641-2653
pubmed: 28424277
Adv Exp Med Biol. 2010;688:60-71
pubmed: 20919646
J Am Soc Nephrol. 2016 Jan;27(1):12-26
pubmed: 26251351
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Feb;1866(2):158856
pubmed: 33221496
J Am Soc Nephrol. 2002 Dec;13(12):3005-15
pubmed: 12444221
Transplantation. 2006 Sep 27;82(6):804-12
pubmed: 17006328
Antioxid Redox Signal. 2011 Aug 15;15(4):1043-83
pubmed: 21294649
PLoS One. 2012;7(9):e45020
pubmed: 23024785
Nephron Exp Nephrol. 2007;106(2):e27-31
pubmed: 17570936
J Diabetes Investig. 2020 Mar;11(2):441-449
pubmed: 31580528
Nat Commun. 2012 Mar 13;3:731
pubmed: 22415822
Nat Genet. 2000 Mar;24(3):251-6
pubmed: 10700177
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7962-7
pubmed: 10393930
Metabolism. 2018 Aug;85:348-360
pubmed: 29462574
Biochem J. 2000 Jul 15;349(Pt 2):385-402
pubmed: 10880336
Mol Biol Cell. 2001 Oct;12(10):3060-73
pubmed: 11598191
Biochim Biophys Acta. 2014 May;1841(5):682-91
pubmed: 24064302
J Clin Invest. 2017 Mar 1;127(3):942-953
pubmed: 28165343
FEBS Lett. 2004 May 21;566(1-3):30-4
pubmed: 15147863
Kidney Int. 2012 Jun;81(11):1075-85
pubmed: 22278020
J Clin Invest. 2017 Mar 1;127(3):912-928
pubmed: 28165339
J Clin Invest. 2011 Oct;121(10):3965-80
pubmed: 21911934
Iran J Kidney Dis. 2013 May 21;7(3):231-4
pubmed: 23689157
Clin J Am Soc Nephrol. 2018 Jan 6;13(1):53-62
pubmed: 29127259
Eur J Pharmacol. 2016 Nov 5;790:83-91
pubmed: 27375075
J Cell Biol. 2012 Jan 9;196(1):115-30
pubmed: 22232703
Biochim Biophys Acta. 2002 Dec 30;1585(2-3):153-62
pubmed: 12531549
Kidney Int. 1992 Sep;42(3):624-31
pubmed: 1383597
J Biol Chem. 2002 Jul 19;277(29):25851-4
pubmed: 12011102
FEBS J. 2013 Nov;280(21):5317-36
pubmed: 23638983
Clin Chem Lab Med. 2010 Feb;48(2):189-98
pubmed: 19958207
J Am Soc Nephrol. 2016 Sep;27(9):2685-700
pubmed: 26823550
Pediatr Nephrol. 1990 Jan;4(1):21-8
pubmed: 2206875
J Biol Chem. 2011 Aug 12;286(32):27855-62
pubmed: 21693702
Kidney Int. 2011 Mar;79(6):663-670
pubmed: 21160462
Biochim Biophys Acta. 2009 Apr;1788(4):797-812
pubmed: 19366594
J Pediatr Hematol Oncol. 2007 May;29(5):347
pubmed: 17483719
J Clin Invest. 2007 Jun;117(6):1585-94
pubmed: 17549255
J Am Soc Nephrol. 2017 Jun;28(6):1707-1715
pubmed: 28404664
Curr Med Chem. 2017;24(12):1238-1275
pubmed: 28078995
BBA Clin. 2017 Feb 13;7:85-96
pubmed: 28275553
Am J Pathol. 1996 Sep;149(3):1009-15
pubmed: 8780404
J Clin Invest. 2001 Dec;108(11):1621-9
pubmed: 11733557
J Cell Biol. 2000 Aug 7;150(3):643-56
pubmed: 10931874
J Am Soc Nephrol. 2015 Jun;26(6):1279-89
pubmed: 25349199
Expert Opin Ther Targets. 2009 Aug;13(8):1013-25
pubmed: 19534571
Adv Enzyme Regul. 2009;49(1):214-21
pubmed: 19534035
Nat Rev Nephrol. 2013 Mar;9(3):154-69
pubmed: 23338210
Nat Genet. 2000 Apr;24(4):349-54
pubmed: 10742096
Nefrologia. 2014;34(4):483-90
pubmed: 25036062
Am J Physiol Renal Physiol. 2010 Oct;299(4):F689-701
pubmed: 20685822
Matrix Biol. 2018 Aug;68-69:230-247
pubmed: 29343457
PLoS One. 2020 Jan 24;15(1):e0228337
pubmed: 31978139
J Am Soc Nephrol. 2014 Apr;25(4):737-44
pubmed: 24459229
Kidney Int. 2009 Jan;75(2):214-26
pubmed: 19116644
FASEB J. 2017 Feb;31(2):771-780
pubmed: 27836988
J Clin Invest. 1978 Jul;62(1):119-23
pubmed: 96141
J Biol Chem. 2002 Jul 19;277(29):25847-50
pubmed: 12011103
Nat Commun. 2019 Jun 19;10(1):2692
pubmed: 31217420
Eur J Cell Biol. 2006 Apr;85(3-4):229-34
pubmed: 16546566
Sci Signal. 2010 Oct 26;3(145):ra77
pubmed: 20978238
Am J Physiol Renal Physiol. 2010 Apr;298(4):F951-61
pubmed: 20071462
Front Pediatr. 2020 Apr 08;8:151
pubmed: 32322566
J Cell Sci. 2002 Dec 1;115(Pt 23):4671-83
pubmed: 12415011
J Am Soc Nephrol. 2008 Jun;19(6):1213-24
pubmed: 18354029
J Biol Chem. 2001 Nov 9;276(45):41543-6
pubmed: 11562357
J Cell Biochem. 2004 Aug 1;92(5):913-22
pubmed: 15258915
Mol Cell. 1998 Mar;1(4):575-82
pubmed: 9660941
Science. 1998 Mar 6;279(5356):1552-5
pubmed: 9488656
Diabetologia. 2012 Nov;55(11):2913-9
pubmed: 22854890
Saudi J Kidney Dis Transpl. 2017 Nov-Dec;28(6):1408-1411
pubmed: 29265055
J Am Soc Nephrol. 2005 Feb;16(2):408-16
pubmed: 15625073
Biochim Biophys Acta. 2008 Sep;1781(9):424-34
pubmed: 18619555
Pediatrics. 2007 Apr;119(4):e907-19
pubmed: 17371932
J Am Soc Nephrol. 2011 Sep;22(9):1621-30
pubmed: 21804090
Arch Neurol. 2006 Mar;63(3):453-7
pubmed: 16533976
Oncotarget. 2016 Apr 5;7(14):19031-44
pubmed: 26980705
Dev Cell. 2009 Sep;17(3):310-22
pubmed: 19758556
N Engl J Med. 2017 Dec 14;377(24):2363-2374
pubmed: 29236630
Nephrol Dial Transplant. 2011 May;26(5):1493-502
pubmed: 20961887
FEBS J. 2013 Dec;280(24):6338-53
pubmed: 24165035
Biochim Biophys Acta. 2013 Jun;1831(6):1060-6
pubmed: 23410840
Nature. 2006 Apr 6;440(7085):818-23
pubmed: 16525419
Kidney Int. 2011 May;79(10):1090-8
pubmed: 21289599
N Engl J Med. 2006 May 4;354(18):1961-3
pubmed: 16672715
Clin Chim Acta. 2010 Dec 14;411(23-24):1906-14
pubmed: 20716442
Am J Pathol. 2011 Nov;179(5):2210-9
pubmed: 21893018
Genes Cells. 2009 May;14(5):597-605
pubmed: 19371379
Nat Rev Nephrol. 2020 Jun;16(6):317-336
pubmed: 32152499
Cell. 2012 Oct 12;151(2):384-99
pubmed: 23063127
PLoS One. 2011;6(9):e25065
pubmed: 21949853
Biochim Biophys Acta. 2014 May;1841(5):692-703
pubmed: 24355909
Trends Mol Med. 2018 Aug;24(8):682-695
pubmed: 29886044
Physiol Rev. 2003 Jan;83(1):253-307
pubmed: 12506131
Nat Rev Nephrol. 2011 Oct 25;8(1):14-21
pubmed: 22025085
Clin J Am Soc Nephrol. 2007 May;2(3):529-42
pubmed: 17699461
Nat Clin Pract Nephrol. 2006 Apr;2(4):221-30
pubmed: 16932428
Front Mol Biosci. 2017 Jun 07;4:37
pubmed: 28638822
Acta Paediatr Suppl. 2005 Mar;94(447):51-4; discussion 37-8
pubmed: 15895713
Pediatr Transplant. 2004 Aug;8(4):329-33
pubmed: 15265156
Internist (Berl). 2019 May;60(5):450-457
pubmed: 30887070
J Lipid Res. 2009 Apr;50 Suppl:S91-6
pubmed: 19017611
Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):849-860
pubmed: 30771382
J Signal Transduct. 2011;2011:563128
pubmed: 21808733
Lab Invest. 2010 Aug;90(8):1209-24
pubmed: 20458275
Annu Rev Biochem. 2009;78:743-68
pubmed: 19231986
Antioxid Redox Signal. 2018 Apr 1;28(10):1008-1026
pubmed: 29121774
Virchows Arch. 2007 Oct;451(4):823-34
pubmed: 17674039
J Cell Mol Med. 2013 Dec;17(12):1598-607
pubmed: 24238063
Pediatr Nephrol. 2005 Feb;20(2):210-6
pubmed: 15605284
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158517
pubmed: 31487557
J Am Soc Nephrol. 2015 Jan;26(1):230-6
pubmed: 25060053
J Biol Chem. 2016 Nov 11;291(46):24054-24064
pubmed: 27687724
Am J Pathol. 2001 Sep;159(3):1069-77
pubmed: 11549599
Endocrinology. 1996 Nov;137(11):4864-70
pubmed: 8895358
EMBO Rep. 2007 Nov;8(11):1019-23
pubmed: 17972901
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16080-5
pubmed: 17901210
Diabetologia. 2017 Mar;60(3):581-584
pubmed: 28004150
Science. 1999 Oct 8;286(5438):312-5
pubmed: 10514378
Front Pharmacol. 2019 Dec 06;10:1336
pubmed: 31866857
J Cell Biol. 2002 Sep 16;158(6):1039-49
pubmed: 12235122
Pediatr Nephrol. 2005 Nov;20(11):1660-3
pubmed: 16133051
Sci Transl Med. 2011 Jun 1;3(85):85ra46
pubmed: 21632984
J Biol Chem. 1995 Dec 22;270(51):30701-8
pubmed: 8530509
Am J Pathol. 2020 Jun;190(6):1211-1223
pubmed: 32194052