Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
10
08
2020
accepted:
03
03
2021
entrez:
17
4
2021
pubmed:
18
4
2021
medline:
19
4
2022
Statut:
epublish
Résumé
The avascular nature of cornea tissue limits its regenerative potential, which may lead to incomplete healing and formation of scars when damaged. Here, we applied micro- and ultrafine porcine urinary bladder matrix (UBM) particulate to promote type 2 immune responses in cornea wounds. Results demonstrated that UBM particulate substantially reduced corneal haze formation as compared to the saline-treated group. Flow cytometry and gene expression analysis showed that UBM particulate suppressed the differentiation of corneal stromal cells into α-smooth muscle actin-positive (αSMA
Identifiants
pubmed: 33863719
pii: 7/16/eabe2635
doi: 10.1126/sciadv.abe2635
pmc: PMC8051883
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY001765
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY008512
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029055
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007057
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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