Locally Advanced Pancreatic Cancer: Percutaneous Management Using Ablation, Brachytherapy, Intra-arterial Chemotherapy, and Intra-tumoral Immunotherapy.
Ablation
Brachytherapy
Cryoablation
Intra-arterial chemotherapy
Intra-tumoral immunotherapy
Irreversible electroporation
Locally advanced pancreatic cancer
Microwave ablation
Radiofrequency ablation
Journal
Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967
Informations de publication
Date de publication:
17 04 2021
17 04 2021
Historique:
accepted:
11
03
2021
entrez:
17
4
2021
pubmed:
18
4
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasms, bearing a terrible prognosis. Stage III tumors, also known as locally advanced pancreatic cancer (LAPC), are unresectable, and current palliative chemotherapy regimens have only modestly improved survival in these patients. At this stage of disease, interventional techniques may be of value and further prolong life. The aim of this review was to explore current literature on locoregional percutaneous management for LAPC. Locoregional percutaneous interventional techniques such as ablation, brachytherapy, and intra-arterial chemotherapy possess cytoreductive abilities and have the potential to increase survival. In addition, recent research demonstrates the immunomodulatory capacities of these treatments. This immune response may be leveraged by combining the interventional techniques with intra-tumoral immunotherapy, possibly creating a durable anti-tumor effect. This multimodality treatment approach is currently being examined in several ongoing clinical trials. The use of certain interventional techniques appears to improve survival in LAPC patients and may work synergistically when combined with immunotherapy. However, definitive conclusions can only be made when large prospective (randomized controlled) trials confirm these results.
Identifiants
pubmed: 33864144
doi: 10.1007/s11912-021-01057-3
pii: 10.1007/s11912-021-01057-3
pmc: PMC8052234
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
68Références
J Exp Clin Cancer Res. 2013 Dec 27;32:106
pubmed: 24370348
Cell Stress Chaperones. 2011 Sep;16(5):495-504
pubmed: 21442384
Eur J Surg Oncol. 2019 Nov;45(11):2166-2172
pubmed: 31227340
Minim Invasive Ther Allied Technol. 2018 Feb;27(1):33-40
pubmed: 29278340
Ann Oncol. 2018 Nov 1;29(11):2163-2174
pubmed: 30295695
J Cancer Res Clin Oncol. 2020 Nov;146(11):2897-2911
pubmed: 32748119
Br J Surg. 2010 Feb;97(2):220-5
pubmed: 20069610
Nat Rev Clin Oncol. 2020 Dec;17(12):725-741
pubmed: 32760014
Front Immunol. 2020 Oct 15;11:575597
pubmed: 33178203
Chin Med J (Engl). 2016 20th Dec;129(24):2920-2925
pubmed: 27958223
Pancreas. 2017 Feb;46(2):e12-e14
pubmed: 28085755
J Dig Dis. 2014 Oct;15(10):561-9
pubmed: 24958092
Gastroenterol Res Pract. 2016;2016:9251375
pubmed: 27051417
J Pancreat Cancer. 2017 Aug 01;3(1):58-65
pubmed: 30631844
Int J Hyperthermia. 2019;36(1):130-138
pubmed: 30676126
J Immunother Cancer. 2020 Jul;8(2):
pubmed: 32675194
Med Oncol. 2017 Mar;34(3):38
pubmed: 28161827
Radiology. 2020 May;295(2):254-272
pubmed: 32208094
Oncoimmunology. 2014 Jan 1;3(1):e27614
pubmed: 24701377
Ann Surg Oncol. 2019 Mar;26(3):800-806
pubmed: 30610562
Minim Invasive Ther Allied Technol. 2017 Dec;26(6):331-337
pubmed: 28417678
Lancet. 2016 Jul 2;388(10039):73-85
pubmed: 26830752
Eur J Surg Oncol. 2016 Sep;42(9):1401-6
pubmed: 26906114
Front Oncol. 2020 Jan 22;10:6
pubmed: 32038984
Hepatobiliary Pancreat Dis Int. 2010 Jun;9(3):306-11
pubmed: 20525559
Liver Int. 2010 Oct;30(9):1305-14
pubmed: 20536713
Medicine (Baltimore). 2016 Mar;95(11):e3098
pubmed: 26986149
Oncol Lett. 2017 Sep;14(3):2838-2844
pubmed: 28927042
HPB (Oxford). 2014 Feb;16(2):119-23
pubmed: 23600801
J Vasc Interv Radiol. 2020 Oct;31(10):1600-1608
pubmed: 32861569
J Hepatobiliary Pancreat Sci. 2013 Aug;20(6):574-7
pubmed: 23591744
Technol Cancer Res Treat. 2017 Jun;16(3):285-294
pubmed: 27193941
Acta Radiol. 2021 Feb;62(2):164-171
pubmed: 32295390
Mol Ther. 2009 Apr;17(4):614-22
pubmed: 19223865
Ann Surg Oncol. 2017 Sep;24(9):2734-2743
pubmed: 28560601
Gland Surg. 2018 Apr;7(2):59-66
pubmed: 29770302
Gastrointest Endosc. 2012 Dec;76(6):1142-51
pubmed: 23021160
Ther Adv Med Oncol. 2020 Sep 10;12:1758835920953728
pubmed: 32973929
Crit Rev Biomed Eng. 2010;38(1):65-78
pubmed: 21175404
Anticancer Res. 1998 Jul-Aug;18(4A):2483-6
pubmed: 9703896
World J Gastroenterol. 2010 Oct 28;16(40):5104-10
pubmed: 20976848
J Cancer Res Ther. 2020;16(2):280-285
pubmed: 32474514
Intern Med. 2018 Nov 15;57(22):3225-3231
pubmed: 29984761
J Vasc Interv Radiol. 2010 Aug;21(8 Suppl):S192-203
pubmed: 20656229
Immunity. 2013 Jul 25;39(1):74-88
pubmed: 23890065
J Gastrointest Oncol. 2018 Apr;9(2):275-281
pubmed: 29755766
J Natl Cancer Inst. 2021 Feb 1;113(2):182-191
pubmed: 32497200
J Surg Res. 2020 Feb;246:260-268
pubmed: 31610354
Eur J Surg Oncol. 2020 May;46(5):811-817
pubmed: 31839436
Oncol Rep. 2016 Aug;36(2):659-68
pubmed: 27278081
J Vasc Interv Radiol. 2017 Mar;28(3):342-348
pubmed: 27993507
Br J Cancer. 2006 Oct 9;95(7):896-905
pubmed: 16953240
Sci Transl Med. 2020 Sep 30;12(563):
pubmed: 32998971
Cryobiology. 2012 Dec;65(3):301-7
pubmed: 22960266
J Cancer Res Ther. 2018;14(7):1455-1462
pubmed: 30589023
Neoplasma. 2016;63(2):269-73
pubmed: 26774149
Int J Radiat Biol. 2020 Mar;96(3):383-389
pubmed: 31977258
J Vasc Interv Radiol. 2018 Dec;29(12):1764-1769
pubmed: 30316676
Oncoimmunology. 2019 Aug 28;8(11):1652532
pubmed: 31646081
Gland Surg. 2013 May;2(2):91-9
pubmed: 25083464
Scand J Gastroenterol. 2019 Feb;54(2):252-258
pubmed: 30907286
Front Immunol. 2013 Jul 11;4:190
pubmed: 23874336
Anticancer Res. 2019 May;39(5):2509-2512
pubmed: 31092446
Oncotarget. 2017 Oct 19;8(60):101795-101807
pubmed: 29254205
Chin Clin Oncol. 2019 Dec;8(6):61
pubmed: 31865711
Int J Colorectal Dis. 2015 Aug;30(8):1091-102
pubmed: 26008728
Ann Oncol. 2015 Sep;26 Suppl 5:v56-68
pubmed: 26314780
Ann Oncol. 2017 Dec 1;28(suppl_12):xii33-xii43
pubmed: 29253115
Gastrointest Endosc. 2019 Jan;89(1):58-66.e3
pubmed: 30120957
Brachytherapy. 2016 Nov - Dec;15(6):859-864
pubmed: 27364870
Oncogene. 2008 Jan 7;27(2):161-7
pubmed: 18176597
Ann Surg Oncol. 2016 May;23(5):1736-43
pubmed: 26714959
Signal Transduct Target Ther. 2020 Oct 23;5(1):215
pubmed: 33093457
Eur Radiol. 2010 Jul;20(7):1786-91
pubmed: 20069424
J Immunother Cancer. 2017 Oct 17;5(1):78
pubmed: 29037259
Medicine (Baltimore). 2017 Dec;96(52):e9535
pubmed: 29384971
Br J Cancer. 2007 Sep 3;97(5):598-604
pubmed: 17667928
Radiology. 2017 Feb;282(2):585-597
pubmed: 27604035
Indian J Cancer. 2015 Dec;52 Suppl 2:e69-74
pubmed: 26728678
J Cancer Res Clin Oncol. 2019 Nov;145(11):2855-2862
pubmed: 31506738
Br J Surg. 2012 Aug;99(8):1083-8
pubmed: 22648697
J Gastrointestin Liver Dis. 2018 Mar;27(1):67-72
pubmed: 29557417
Ann Surg Oncol. 2010 Apr;17(4):1187-93
pubmed: 20033323
Int J Surg. 2015 Sep;21 Suppl 1:S34-9
pubmed: 26118600
Pancreatology. 2017 Nov - Dec;17(6):962-966
pubmed: 29037917
Nat Rev Cancer. 2014 Mar;14(3):199-208
pubmed: 24561446
J BUON. 2020 May-Jun;25(3):1643-1649
pubmed: 32862617
Ann Surg Oncol. 2009 Jul;16(7):1727-33
pubmed: 19396496
Dig Surg. 2015;32(2):90-7
pubmed: 25765775
Postgrad Med J. 2011 Feb;87(1024):89-95
pubmed: 21131612
Langenbecks Arch Surg. 2013 Jan;398(1):63-9
pubmed: 23053459
Lancet. 2011 Aug 13;378(9791):607-20
pubmed: 21620466
Ann Surg. 2015 Sep;262(3):486-94; discussion 492-4
pubmed: 26258317
Radiology. 2015 Aug;276(2):416-25
pubmed: 25822472
Surg Endosc. 2018 Sep;32(9):4022-4028
pubmed: 29766302
J Hematol Oncol. 2020 Jun 29;13(1):84
pubmed: 32600470
World J Clin Cases. 2020 Sep 6;8(17):3743-3750
pubmed: 32953850
Cancers (Basel). 2018 Jan 10;10(1):
pubmed: 29320420
Clin Cancer Res. 2013 Oct 1;19(19):5381-9
pubmed: 23788581
Cell Death Differ. 2007 Jul;14(7):1237-43
pubmed: 17431418
Nat Commun. 2019 Feb 22;10(1):899
pubmed: 30796212
J Huazhong Univ Sci Technolog Med Sci. 2016 Apr;36(2):205-210
pubmed: 27072963
BMC Cancer. 2018 May 25;18(1):596
pubmed: 29801474
J Vasc Interv Radiol. 2013 Oct;24(10):1513-20
pubmed: 24070507
Ann Surg. 2009 May;249(5):814-23
pubmed: 19387320
Ann Surg. 2000 May;231(5):752-61
pubmed: 10767797
PLoS One. 2012;7(7):e40847
pubmed: 22815840
JCI Insight. 2018 Dec 6;3(23):
pubmed: 30518694
Abdom Radiol (NY). 2019 Aug;44(8):2801-2808
pubmed: 31025067
Clinics (Sao Paulo). 2018 Dec 10;73(suppl 1):e557s
pubmed: 30540123
J Am Coll Surg. 2014 Feb;218(2):179-87
pubmed: 24315888
Cancer Immunol Res. 2019 Oct;7(10):1714-1726
pubmed: 31409607
J Vasc Interv Radiol. 2010 Aug;21(8 Suppl):S187-91
pubmed: 20656228
Cell Rep. 2019 Oct 8;29(2):406-421.e5
pubmed: 31597100