Anticancer activity of limonene: A systematic review of target signaling pathways.
cancer
chemopreventive activity
limonene
molecular mechanisms
monoterpene
natural product.
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
26
02
2021
received:
21
09
2020
accepted:
26
03
2021
pubmed:
18
4
2021
medline:
30
9
2021
entrez:
17
4
2021
Statut:
ppublish
Résumé
Limonene (LIM) is a monoterpene, which is abundant in essential oils of Citrus fruits peels (Rutaceae). More recently, LIM, as a potential natural anticancer compound, has attracted major attention and exerted a chemopreventive activity, stimulating the detoxification of carcinogenic compounds and limiting tumor growth and angiogenesis in various cancer models. Twenty-six (26) articles were selected based on previously established criteria. Anticancer activity of LIM was related to the inhibition of tumor initiation, growth, and angiogenesis and the induction of cancer cells apoptosis. LIM was able to increase Bax expression, release cytochrome c, and activate the caspase pathway. In addition, LIM increased the expression of p53 and decreased the activity of Ras/Raf/MEK/ERK and PI3K/Akt pathways. LIM also decreased the expression of VEGF and increased the activities of the Man-6-P / IGF2R and TGF-βIIR receptors. These results highlight LIM as an abundant natural molecule with low toxicity and pleiotropic pharmacological activity in cancer cells, targeting various cell-signaling pathways critically involved in the initiation, growth, and chemoresistance of cancer cells.
Substances chimiques
Limonene
9MC3I34447
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4957-4970Subventions
Organisme : Financiadora de Estudos e Projetos-Brasil (FINEP)
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil
Organisme : Fundação de Apoio à Pesquisa e a Inovação Tecnológica do Estado de Sergipe (Fapitec/SE)-Brasil
Organisme : Conselho Conselho Nacional de Desenvolvimento Científico e Tecnológico-Brasil (CNPq)
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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