Thirdhand smoke associations with the gut microbiomes of infants admitted to a neonatal intensive care unit: An observational study.
Breastmilk
Gut microbiome
NICU
Neonatal ICU
THS
Thirdhand smoke
Tobacco carcinogens
Tobacco toxicants
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
15
12
2020
revised:
06
04
2021
accepted:
08
04
2021
pubmed:
19
4
2021
medline:
1
7
2021
entrez:
18
4
2021
Statut:
ppublish
Résumé
Microbiome differences have been found in adults who smoke cigarettes compared to non-smoking adults, but the impact of thirdhand smoke (THS; post-combustion tobacco residue) on hospitalized infants' rapidly developing gut microbiomes is unexplored. Our aim was to explore gut microbiome differences in infants admitted to a neonatal ICU (NICU) with varying THS-related exposure. Forty-three mother-infant dyads (household member[s] smoke cigarettes, n = 32; no household smoking, n = 11) consented to a carbon monoxide-breath sample, bedside furniture nicotine wipes, infant-urine samples (for cotinine [nicotine's primary metabolite] assays), and stool collection (for 16S rRNA V4 gene sequencing). Negative binomial regression modeled relative abundances of 8 bacterial genera with THS exposure-related variables (i.e., household cigarette use, surface nicotine, and infant urine cotinine), controlling for gestational age, postnatal age, antibiotic use, and breastmilk feeding. Microbiome-diversity outcomes were modeled similarly. Bayesian posterior probabilities (PP) ≥75.0% were considered meaningful. A majority of infants (78%) were born pre-term. Infants from non-smoking homes and/or with lower NICU-furniture surface nicotine had greater microbiome alpha-diversity compared to infants from smoking households (PP ≥ 75.0%). Associations (with PP ≥ 75.0%) of selected bacterial genera with urine cotinine, surface nicotine, and/or household cigarette use were evidenced for 7 (of 8) modeled genera. For example, lower Bifidobacterium relative abundance associated with greater furniture nicotine (IRR<0.01 [<0.01, 64.02]; PP = 87.1%), urine cotinine (IRR = 0.08 [<0.01,2.84]; PP = 86.9%), and household smoking (IRR<0.01 [<0.01, 7.38]; PP = 96.0%; FDR p < 0.05). THS-related exposure was associated with microbiome differences in NICU-admitted infants. Additional research on effects of tobacco-related exposures on healthy infant gut-microbiome development is warranted.
Identifiants
pubmed: 33865820
pii: S0013-9351(21)00474-6
doi: 10.1016/j.envres.2021.111180
pmc: PMC8187318
mid: NIHMS1696697
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Tobacco Smoke Pollution
0
Cotinine
K5161X06LL
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111180Subventions
Organisme : NIDA NIH HHS
ID : P30 DA012393
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL107404
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD088847
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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