Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses.

Animals Bioaccumulation Biomarkers / metabolism Embryo, Nonmammalian / metabolism Macrolides Oxidative Stress Water Pollutants, Chemical / metabolism Zebrafish / metabolism
Aquatic toxicology Emerging pollutants MALDI-MS imaging Macrocyclic lactones Veterinary antiparasitics

Journal

Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476

Informations de publication

Date de publication:
15 Aug 2021
Historique:
received: 10 12 2020
revised: 14 03 2021
accepted: 04 04 2021
pubmed: 19 4 2021
medline: 16 6 2021
entrez: 18 4 2021
Statut: ppublish

Résumé

Moxidectin is an antiparasitic drug belonging to the class of the macrocyclic lactones, subgroup mylbemicins. It is used worldwide in veterinary practice, but little is known about its potential environmental risks. Thus, we used the zebrafish embryo as a model system to study the potential effects of moxidectin on aquatic non-target organisms. The analyses were performed in two experimental sets: (1) acute toxicity and apical endpoints were characterized, with biomarker assays providing information on the activity levels of catalase (CAT), glutathione S-transferase (GST), lactate dehydrogenase (LDH), and acetylcholinesterase (AChE); and (2) internal concentration and spatial distribution of moxidectin were determined using ultraperformance liquid chromatography quadrupole-time-of-flight mass spectrometry (UPLC-QToF-MS) and matrix-assisted laser desorption/ionization-MS imaging (MALDI-MSi). The acute toxicity to zebrafish embryos (96 hpf) appeared mainly as a decrease in hatching rates (EC

Identifiants

DOI: 10.1016/j.envpol.2021.117096 PMID: 33866217
pubmed: 33866217
pii: S0269-7491(21)00678-3
doi: 10.1016/j.envpol.2021.117096
pii:
doi:

Substances chimiques

Biomarkers 0
Macrolides 0
Water Pollutants, Chemical 0
moxidectin NGU5H31YO9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117096

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Marta Silva Muniz (MS)

Laboratory for Risk Assessment of Novel Technologies (LabRisk), Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.

Katharina Halbach (K)

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.

Igor Cauê Alves Araruna (IC)

Laboratory for Risk Assessment of Novel Technologies (LabRisk), Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.

Rafael Xavier Martins (RX)

Laboratory for Risk Assessment of Novel Technologies (LabRisk), Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.

Bettina Seiwert (B)

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.

Oliver Lechtenfeld (O)

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.

Thorsten Reemtsma (T)

Department of Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany; Institute of Analytical Chemistry, University of Leipzig, Leipzig, Germany.

Davi Farias (D)

Laboratory for Risk Assessment of Novel Technologies (LabRisk), Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil. Electronic address: davi@dbm.ufpb.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Absorption › Absorption physiologique › Bioaccumulation › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Moxidectin toxicity to zebrafish embryos:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Moxidectin toxicity to zebrafish embryos:...