A Family Affair: Addressing the Challenges of Factor H and the Related Proteins.
challenges - development directions
complement system
factor H (FH)
factor H-like protein 1
factor H-related protein
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
01
2021
accepted:
08
03
2021
entrez:
19
4
2021
pubmed:
20
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders. Recently, a family of proteins has been suggested to be of vital importance in conditions characterized by complement dysregulation: the human Factor H (FH) family. This group of proteins consists of FH, Factor H-like protein 1 and five Factor H-related proteins. The FH family has been linked to infectious, vascular, eye, kidney and autoimmune diseases. In contrast to FH, the functions of the other highly homologous proteins are largely unknown and, hence, their role in the different disease-specific pathogenic mechanisms remains elusive. In this perspective review, we address the major challenges ahead in this emerging area, including 1) the controversies about the functional roles of the FH protein family, 2) the discrepancies in quantification of the FH protein family, 3) the unmet needs for validated tools and 4) limitations of animal models. Next, we also discuss the opportunities that exist for the immunology community. A strong multidisciplinary approach is required to solve these obstacles and is only possible through interdisciplinary collaboration between biologists, chemists, geneticists and physicians. We position this review in light of our own perspective, as principal investigators of the SciFiMed Consortium, a consortium aiming to create a comprehensive analytical system for the quantitative and functional assessment of the entire FH protein family.
Identifiants
pubmed: 33868311
doi: 10.3389/fimmu.2021.660194
pmc: PMC8044877
doi:
Substances chimiques
CFH protein, human
0
Receptors, Complement
0
factor H receptors
0
Complement Factor H
80295-65-4
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
660194Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Poppelaars, Goicoechea de Jorge, Jongerius, Baeumner, Steiner, Józsi, Toonen, Pauly and the SciFiMed consortium.
Déclaration de conflit d'intérêts
MS was employed by Microcoat Biotechnologie GmbH. ET was employed by Hycult Biotech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Immunol. 2016 Sep;77:89-96
pubmed: 27490940
J Am Soc Nephrol. 2017 May;28(5):1462-1474
pubmed: 27932477
J Biol Chem. 1993 Feb 5;268(4):2904-8
pubmed: 8428964
J Immunol. 1991 May 1;146(9):3190-6
pubmed: 1826708
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16651-6
pubmed: 17921253
F1000Res. 2017 Jun 8;6:851
pubmed: 28713558
Immunogenetics. 2006 Nov;58(11):883-93
pubmed: 17028856
Front Immunol. 2017 Sep 19;8:1145
pubmed: 28974948
Front Immunol. 2020 Dec 10;11:578069
pubmed: 33362763
Nat Genet. 2006 Oct;38(10):1173-7
pubmed: 16998489
Hum Mol Genet. 2013 Dec 1;22(23):4857-69
pubmed: 23873044
Mol Immunol. 2004 May;41(1):81-4
pubmed: 15140578
J Am Soc Nephrol. 2016 May;27(5):1413-25
pubmed: 26432903
Eur J Immunol. 1987 Oct;17(10):1485-9
pubmed: 2445583
J Immunol. 2019 Apr 1;202(7):2082-2094
pubmed: 30745459
Nat Rev Immunol. 2009 Oct;9(10):729-40
pubmed: 19730437
J Am Soc Nephrol. 2018 Apr;29(4):1141-1153
pubmed: 29335241
Am J Kidney Dis. 2012 Jul;60(1):121-5
pubmed: 22503529
Semin Immunol. 2019 Oct;45:101341
pubmed: 31757608
J Clin Invest. 2013 Jun;123(6):2434-46
pubmed: 23728178
J Immunol. 1992 May 15;148(10):3313-8
pubmed: 1533657
Immunobiology. 2016 Nov;221(11):1247-58
pubmed: 27475991
F1000Res. 2017 Feb 17;6:161
pubmed: 28357047
Kidney Int Rep. 2019 Jun 19;4(10):1387-1400
pubmed: 31701048
Clin Exp Immunol. 2000 Aug;121(2):406-15
pubmed: 10931160
Elife. 2014 Dec 23;3:
pubmed: 25534642
Immunogenetics. 1999 Jun;49(6):549-52
pubmed: 10380701
J Immunol. 2015 May 15;194(10):4963-73
pubmed: 25855355
Nat Methods. 2016 Oct;13(10):823-7
pubmed: 27595404
Sci Rep. 2018 Jan 26;8(1):1643
pubmed: 29374201
Mol Immunol. 2010 Aug;47(13):2187-97
pubmed: 20580090
J Steroid Biochem Mol Biol. 2016 Feb;156:40-2
pubmed: 26655410
Blood Adv. 2019 Feb 26;3(4):621-632
pubmed: 30804016
Mol Immunol. 2015 Sep;67(1):12-20
pubmed: 25824240
J Clin Invest. 2003 Apr;111(8):1181-90
pubmed: 12697737
J Neuroinflammation. 2019 Dec 28;16(1):279
pubmed: 31883521
Ophthalmology. 2019 Oct;126(10):1422-1423
pubmed: 31543111
Clin Dev Immunol. 2012;2012:962702
pubmed: 23227092
Kidney Int Rep. 2017 Nov 29;3(2):426-438
pubmed: 29725647
J Immunol. 2020 Oct 1;205(7):1778-1786
pubmed: 32848031
Mol Immunol. 2018 Oct;102:84-88
pubmed: 29933889
Front Immunol. 2020 Jul 16;11:1297
pubmed: 32765490
Front Immunol. 2018 Nov 20;9:2664
pubmed: 30515158
J Am Soc Nephrol. 2020 Feb;31(2):241-256
pubmed: 31980588
Ophthalmology. 2018 Jul;125(7):1064-1074
pubmed: 29398083
J Immunol. 2008 Dec 1;181(11):8068-76
pubmed: 19017999
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3056-64
pubmed: 19264882
J Exp Med. 2007 Jun 11;204(6):1249-56
pubmed: 17517971
Genetica. 2002 Mar;114(2):157-61
pubmed: 12041828
Eur J Immunol. 1991 Mar;21(3):799-802
pubmed: 1826264
Front Immunol. 2018 Apr 24;9:848
pubmed: 29740447
Nat Genet. 2011 Mar 13;43(4):321-7
pubmed: 21399633
Eur J Immunol. 1989 Sep;19(9):1765-8
pubmed: 2529127
J Immunol. 2017 Dec 1;199(11):3828-3839
pubmed: 29084837
Nat Rev Nephrol. 2016 Jul;12(7):383-401
pubmed: 27211870
Nat Immunol. 2017 Nov 16;18(12):1288-1298
pubmed: 29144501
Nature. 2016 May 25;533(7604):452-4
pubmed: 27225100
J Am Soc Nephrol. 2016 Sep;27(9):2894-905
pubmed: 26825529
Semin Thromb Hemost. 2001 Jun;27(3):191-9
pubmed: 11446652
J Am Soc Nephrol. 2016 Oct;27(10):3187-3194
pubmed: 26940089
Cell Mol Life Sci. 2017 May;74(9):1605-1624
pubmed: 27942748
Front Immunol. 2015 Jun 02;6:262
pubmed: 26082779
J Biol Chem. 2001 Mar 2;276(9):6747-54
pubmed: 11058592
Protein Expr Purif. 2011 Apr;76(2):254-63
pubmed: 21146613
J Immunol. 2014 Nov 15;193(10):4962-70
pubmed: 25305316
Nat Rev Immunol. 2019 Aug;19(8):503-516
pubmed: 31048789
J Immunol. 2013 Jul 15;191(2):912-21
pubmed: 23772024
J Am Soc Nephrol. 2015 May;26(5):1195-204
pubmed: 25205734
J Am Soc Nephrol. 2018 Feb;29(2):661-669
pubmed: 29114042
Front Immunol. 2016 Nov 28;7:542
pubmed: 27965669
J Immunol. 2010 Jan 15;184(2):912-21
pubmed: 20008295
Front Immunol. 2017 May 18;8:571
pubmed: 28572805
Immunobiology. 2016 Jun;221(6):709-14
pubmed: 26004345
Semin Cell Dev Biol. 2019 Jan;85:122-131
pubmed: 29305301
J Immunol. 2012 Aug 15;189(4):1858-67
pubmed: 22786770
Eur J Hum Genet. 2005 Mar;13(3):321-9
pubmed: 15562282
Mol Immunol. 2017 Sep;89:2-9
pubmed: 28601357
Clin Immunol. 2001 Jul;100(1):118-26
pubmed: 11414752
Proteomics. 2017 Mar;17(6):
pubmed: 27647805
Biochem J. 1989 Mar 15;258(3):927-30
pubmed: 2525027
Arthritis Rheum. 2011 Apr;63(4):1076-85
pubmed: 21452327
J Biol Chem. 1991 Jun 25;266(18):12015-20
pubmed: 1711047
J Biol Chem. 1990 Feb 25;265(6):3193-201
pubmed: 1689298
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3963-7
pubmed: 2940596
Biochem J. 1988 Jan 15;249(2):593-602
pubmed: 2963625
Nat Commun. 2020 Feb 7;11(1):778
pubmed: 32034129
Front Immunol. 2020 Jun 19;11:1123
pubmed: 32636836
Am J Kidney Dis. 2002 Jan;39(1):24-7
pubmed: 11774097
Clin Exp Immunol. 2008 Jan;151(1):1-13
pubmed: 18081690
J Immunol. 2005 May 15;174(10):6250-6
pubmed: 15879123
J Immunol. 2013 Jun 1;190(11):5712-21
pubmed: 23616575
Blood. 2011 Oct 27;118(17):4705-13
pubmed: 21860027
Blood. 2009 Sep 17;114(12):2439-47
pubmed: 19528535
J Exp Med. 1976 Nov 2;144(5):1147-63
pubmed: 62817
Nat Genet. 2002 Aug;31(4):424-8
pubmed: 12091909
Kidney Int. 2017 Oct;92(4):942-952
pubmed: 28673452
Front Immunol. 2018 Jul 12;9:1607
pubmed: 30050540
Nat Genet. 2010 Sep;42(9):772-6
pubmed: 20694013
F1000Res. 2015 Sep 07;4:691
pubmed: 26834988
Acta Ophthalmol. 2014 Dec;92(8):745-8
pubmed: 24847905
FEBS Lett. 1999 Dec 3;462(3):345-52
pubmed: 10622723
Kidney Int. 2018 Feb;93(2):470-481
pubmed: 28941939
Kidney Int. 2017 Oct;92(4):953-963
pubmed: 28637589
Kidney Int. 2010 Aug;78(3):279-86
pubmed: 20445496
J Immunol Methods. 2013 Apr 30;390(1-2):63-73
pubmed: 23376722
Immunol Today. 1994 Mar;15(3):121-6
pubmed: 8172644
PLoS Genet. 2011 May;7(5):e1002079
pubmed: 21637784
J Am Soc Nephrol. 2006 Jan;17(1):170-7
pubmed: 16338962
Hum Mol Genet. 2010 Dec 1;19(23):4694-704
pubmed: 20843825
J Clin Invest. 1995 Mar;95(3):1054-61
pubmed: 7883953
Mol Oncol. 2019 Dec;13(12):2531-2553
pubmed: 31365168
J Am Soc Nephrol. 2018 Jun;29(6):1649-1661
pubmed: 29588430
Kidney Int. 2017 Oct;92(4):876-887
pubmed: 28729035
Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4433-E4442
pubmed: 29686068
Kidney Int. 2015 Dec;88(6):1314-1322
pubmed: 26221753
Kidney Int. 2018 Jul;94(1):150-158
pubmed: 29759419
J Biol Chem. 2012 Jun 1;287(23):19528-36
pubmed: 22518841
Front Immunol. 2017 Oct 18;8:1328
pubmed: 29093712
PLoS Genet. 2007 Mar 16;3(3):e41
pubmed: 17367211
Pediatr Infect Dis J. 2015 Oct;34(10):1115-7
pubmed: 26135246
J Immunol. 2018 Jan 1;200(1):316-326
pubmed: 29187587
Trends Immunol. 2015 Jun;36(6):374-84
pubmed: 25979655
Nanomedicine. 2016 May;12(4):1023-1031
pubmed: 26733258
J Immunol. 2016 Nov 1;197(9):3471-3480
pubmed: 27671112
Hum Genet. 2020 Jun;139(6-7):961-980
pubmed: 32067109
J Immunol. 1983 Jun;130(6):2821-4
pubmed: 6222117
Nat Commun. 2019 Jul 4;10(1):2961
pubmed: 31273197
PLoS One. 2013 Nov 18;8(11):e78617
pubmed: 24260121
Handb Exp Pharmacol. 2020;257:177-196
pubmed: 31628600
Nature. 2011 Oct 05;478(7367):76-81
pubmed: 21979047
Science. 1976 Sep 10;193(4257):1011-3
pubmed: 948757
Front Immunol. 2018 Aug 02;9:1727
pubmed: 30116238
Clin Exp Immunol. 1988 Sep;73(3):484-8
pubmed: 2463123
J Exp Med. 1965 Aug 1;122:277-98
pubmed: 14316946
Vopr Med Khim. 2001 Jan-Feb;47(1):91-7
pubmed: 11386002
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90
pubmed: 23487775
J Immunol. 2017 Jul 1;199(1):292-303
pubmed: 28533443
Mol Immunol. 2009 Jan;46(3):335-44
pubmed: 19084272
Immunogenetics. 1995;42(4):268-74
pubmed: 7672821
Mol Immunol. 2007 Apr;44(10):2697-706
pubmed: 17208302
Nat Rev Nephrol. 2019 Mar;15(3):129-143
pubmed: 30692664
J Physiol. 2020 Sep;598(18):3793-3801
pubmed: 32666574
Immunogenetics. 2004 May;56(2):77-82
pubmed: 15118848
PLoS One. 2013 Apr 16;8(4):e60352
pubmed: 23613724
Mol Immunol. 2015 Sep;67(1):31-42
pubmed: 25843230
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3268-72
pubmed: 1067618
J Biol Chem. 2011 Apr 1;286(13):11082-90
pubmed: 21270465
Mol Immunol. 2009 Jun;46(10):1942-50
pubmed: 19411110
Invest Ophthalmol Vis Sci. 2008 May;49(5):1983-90
pubmed: 18436830
Immunobiology. 2019 Sep;224(5):625-631
pubmed: 31519376
Semin Immunol. 2016 Jun;28(3):260-7
pubmed: 27282113
J Clin Invest. 2014 Jan;124(1):145-55
pubmed: 24334459
Front Immunol. 2018 Apr 17;9:729
pubmed: 29719534
Front Immunol. 2018 Jul 23;9:1691
pubmed: 30083158
J Biol Chem. 1997 Feb 28;272(9):5627-34
pubmed: 9038172
Kidney Int. 2011 Aug;80(4):397-404
pubmed: 21677636