Genetic Complexity of Sinoatrial Node Dysfunction.
GIRK4
HCN4
Nav1.5
atrial fibrillation
calsequestrin-2
genetics
sick sinus syndrome
sinoatrial node dysfunction
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
01
2021
accepted:
01
03
2021
entrez:
19
4
2021
pubmed:
20
4
2021
medline:
20
4
2021
Statut:
epublish
Résumé
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing abnormal heart rhythm. Individuals with SND have a variety of symptoms including sinus bradycardia, sinus arrest, SAN block, bradycardia/tachycardia syndrome, and syncope. Importantly, individuals with SND report chronotropic incompetence in response to stress and/or exercise. SND may be genetic or secondary to systemic or cardiovascular conditions. Current management of patients with SND is limited to the relief of arrhythmia symptoms and pacemaker implantation if indicated. Lack of effective therapeutic measures that target the underlying causes of SND renders management of these patients challenging due to its progressive nature and has highlighted a critical need to improve our understanding of its underlying mechanistic basis of SND. This review focuses on current information on the genetics underlying SND, followed by future implications of this knowledge in the management of individuals with SND.
Identifiants
pubmed: 33868385
doi: 10.3389/fgene.2021.654925
pmc: PMC8047474
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
654925Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL146969
Pays : United States
Informations de copyright
Copyright © 2021 Wallace, El Refaey, Mesirca, Hund, Mangoni and Mohler.
Déclaration de conflit d'intérêts
The reviewer HZ declared a past co-authorship with the authors PM and MM to the handling editor. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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