Impact of copy number variant and single nucleotide polymorphism of the programmed death-ligand 1 gene, programmed death-ligand 1 protein expression and therapy regimens on overall survival in a large group of Caucasian patients with non-small cell lung carcinoma.
copy number variation
non-small cell lung cancer
programmed death-ligand 1
protein expression
single nucleotide polymorphism
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
04
11
2020
accepted:
14
01
2021
entrez:
19
4
2021
pubmed:
20
4
2021
medline:
20
4
2021
Statut:
ppublish
Résumé
Anti-programmed death-1 or anti-programmed death-ligand 1 (PD-L1) blockade may be ineffective in some patients with non-small cell lung cancer (NSCLC) with high percentage of tumor cells with PD-L1 expression. In addition, immunotherapy may provide great benefits in patients without PD-L1 expression. The present study assessed PD-L1 protein expression by immunohistochemistry, copy number variation (CNV) of
Identifiants
pubmed: 33868487
doi: 10.3892/ol.2021.12710
pii: OL-0-0-12710
pmc: PMC8045160
doi:
Types de publication
Journal Article
Langues
eng
Pagination
449Informations de copyright
Copyright: © Grenda et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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