Glycoconjugate vaccines against
Capsular polysaccharide
Enteric fever
HPAEC-PAD
O-Antigen
Typhoid
Vi
Journal
Biophysical reviews
ISSN: 1867-2450
Titre abrégé: Biophys Rev
Pays: Germany
ID NLM: 101498573
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
12
11
2020
accepted:
25
02
2021
pubmed:
20
4
2021
medline:
20
4
2021
entrez:
19
4
2021
Statut:
epublish
Résumé
The global spread of enteric disease, the increasingly limited options for antimicrobial treatment and the need for effective eradication programs have resulted in an increased demand for glycoconjugate enteric vaccines, made with carbohydrate-based membrane components of the pathogen, and their precise characterisation. A set of physico-chemical and immunological tests are employed for complete vaccine characterisation and to ensure their consistency, potency, safety and stability, following the relevant World Health Organization and Pharmacopoeia guidelines. Variable requirements for analytical methods are linked to conjugate structure, carrier protein nature and size and
Identifiants
pubmed: 33868505
doi: 10.1007/s12551-021-00791-z
pii: 791
pmc: PMC8035613
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
221-246Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare no conflict of interest.