Increased regulatory T cells in peripheral blood of children with eosinophilic esophagitis.
Eosinophilic esophagitis
Gastroesophageal reflux disease
Peripheral blood mononuclear cells
Regulatory T cells
Journal
Gastroenterology and hepatology from bed to bench
ISSN: 2008-2258
Titre abrégé: Gastroenterol Hepatol Bed Bench
Pays: Iran
ID NLM: 101525875
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
19
4
2021
pubmed:
20
4
2021
medline:
20
4
2021
Statut:
ppublish
Résumé
Considering the allergic basis of Eosinophilic esophagitis (EoE), this study was conducted to evaluate peripheral blood Tregs in children with EoE. Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of gastrointestinal tract. Regulatory T cells (Tregs) have a confirmed role in allergic disorders. Children with EoE, gastroesophageal reflux disease (GERD) and healthy controls (HC) (10 subjects in each group) were recruited after diagnosis by a pediatric gastroenterologist and allergist. After obtaining informed written consent, peripheral blood was obtained. Peripheral blood mononuclear cells were isolated by Ficoll gradient centrifugation. Flowcytometry was used to enumerate peripheral blood Tregs (CD CD4 Peripheral blood Tregs increase in patients with EoE as compared to healthy controls, which may be indicative of a feedback mechanism to regulate inflammatory responses.
Sections du résumé
AIM
OBJECTIVE
Considering the allergic basis of Eosinophilic esophagitis (EoE), this study was conducted to evaluate peripheral blood Tregs in children with EoE.
BACKGROUND
BACKGROUND
Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of gastrointestinal tract. Regulatory T cells (Tregs) have a confirmed role in allergic disorders.
METHODS
METHODS
Children with EoE, gastroesophageal reflux disease (GERD) and healthy controls (HC) (10 subjects in each group) were recruited after diagnosis by a pediatric gastroenterologist and allergist. After obtaining informed written consent, peripheral blood was obtained. Peripheral blood mononuclear cells were isolated by Ficoll gradient centrifugation. Flowcytometry was used to enumerate peripheral blood Tregs (CD
RESULTS
RESULTS
CD4
CONCLUSION
CONCLUSIONS
Peripheral blood Tregs increase in patients with EoE as compared to healthy controls, which may be indicative of a feedback mechanism to regulate inflammatory responses.
Types de publication
Journal Article
Langues
eng
Pagination
25-30Informations de copyright
©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
Références
Int Arch Allergy Immunol. 2012;157(4):349-53
pubmed: 22123238
World J Gastroenterol. 2016 Feb 7;22(5):1800-10
pubmed: 26855539
Aliment Pharmacol Ther. 2015 Apr;41(7):662-70
pubmed: 25684441
PLoS One. 2015 Nov 20;10(11):e0142881
pubmed: 26587591
Nat Genet. 2010 Apr;42(4):289-91
pubmed: 20208534
Annu Rev Pathol. 2016 May 23;11:365-93
pubmed: 26925500
J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):283-9
pubmed: 20639775
J Transl Med. 2014 May 12;12:125
pubmed: 24886492
Allergy. 2011 May;66(5):705-7
pubmed: 21470243
Allergol Immunopathol (Madr). 2019 Sep - Oct;47(5):431-436
pubmed: 31178311
Ann Clin Lab Sci. 2009 Spring;39(2):99-107
pubmed: 19429794
Am J Gastroenterol. 2012 Feb;107(2):215-21
pubmed: 21971538