Endothelial Glycocalyx Disorders May Be Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model.

diabetes endothelium glycocalyx inflammation lipopolysaccharide

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 30 10 2020
accepted: 03 02 2021
entrez: 19 4 2021
pubmed: 20 4 2021
medline: 20 4 2021
Statut: epublish

Résumé

In diabetes mellitus (DM) patients, the morbidity of infectious disease is increased, and these infections can easily progress from local to systemic infection. Sepsis is a characteristic of organ failure related to microcirculation disorders resulting from endothelial cell injury, whose most frequent comorbidity in patients is DM. The aim of the present study was to evaluate the influence of infection on DM-induced microvascular damage on inflammation and pulmonary endothelial structure using an experimental endotoxemia model. Lipopolysaccharide (LPS; 15 mg/kg) was injected intraperitoneally into 10-week-old male C57BLKS/J Iar

Identifiants

pubmed: 33869173
doi: 10.3389/fcell.2021.623582
pmc: PMC8047120
doi:

Types de publication

Journal Article

Langues

eng

Pagination

623582

Informations de copyright

Copyright © 2021 Sampei, Okada, Tomita, Takada, Suzuki, Kinoshita, Kobayashi, Fukuda, Kawasaki, Nishio, Yano, Muraki, Fukuda, Suzuki, Miyazaki, Watanabe, Doi, Yoshida, Suzuki, Yoshida, Kushimoto and Ogura.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

J Clin Med. 2019 Aug 27;8(9):
pubmed: 31462009
Am J Trop Med Hyg. 2015 Mar;92(3):611-6
pubmed: 25624405
Pflugers Arch. 2007 Jun;454(3):345-59
pubmed: 17256154
Nat Clin Pract Endocrinol Metab. 2005 Dec;1(2):100-10
pubmed: 16929378
Diabetologia. 1992 Aug;35(8):771-6
pubmed: 1511805
Metabolism. 2009 Apr;58(4):443-8
pubmed: 19303962
Diabetes. 2003 Nov;52(11):2795-804
pubmed: 14578299
Diabetes. 2015 Oct;64(10):e37
pubmed: 26405279
Atherosclerosis. 2014 Jun;234(2):335-43
pubmed: 24727235
Crit Care. 2017 Oct 23;21(1):261
pubmed: 29058634
Basic Res Cardiol. 2010 Nov;105(6):687-701
pubmed: 20859744
Cardiovasc Res. 2010 Jul 15;87(2):300-10
pubmed: 20462866
Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1282-91
pubmed: 12234777
PLoS One. 2017 Oct 12;12(10):e0186116
pubmed: 29023478
PLoS One. 2020 Mar 11;15(3):e0229919
pubmed: 32160234
J Clin Invest. 2017 Nov 1;127(11):4124-4135
pubmed: 28990935
Eur J Clin Microbiol Infect Dis. 2012 Apr;31(4):379-88
pubmed: 21805196
Physiol Rev. 2003 Jan;83(1):183-252
pubmed: 12506130
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Diabetes. 2006 Apr;55(4):1127-32
pubmed: 16567538
Shock. 2020 Sep;54(3):386-393
pubmed: 31764619
Sci Rep. 2017 Aug 9;7(1):7633
pubmed: 28794498
Clin Infect Dis. 2005 Aug 1;41(3):281-8
pubmed: 16007521
Sci Rep. 2018 Nov 30;8(1):17523
pubmed: 30504908
J Surg Res. 2011 Jan;165(1):136-41
pubmed: 19560161
Crit Care. 2015 Jan 28;19:26
pubmed: 25887223
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Cell Death Dis. 2019 Oct 14;10(10):778
pubmed: 31611559
Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539
pubmed: 29750566
Cell Metab. 2007 Nov;6(5):386-97
pubmed: 17983584
Histochem Cell Biol. 2015 Feb;143(2):225-34
pubmed: 25534591
J Int Med Res. 2020 Jul;48(7):300060520939746
pubmed: 32722979
N Engl J Med. 2009 Mar 26;360(13):1283-97
pubmed: 19318384
Immunol Rev. 2015 May;265(1):130-42
pubmed: 25879289
Diabetes. 2006 Feb;55(2):480-6
pubmed: 16443784
Am J Med Sci. 2016 Feb;351(2):201-11
pubmed: 26897277
Crit Care. 2018 Nov 22;22(1):322
pubmed: 30466493
Circ J. 2015;79(7):1511-9
pubmed: 25891890
Microcirculation. 2020 Jul;27(5):e12617
pubmed: 32125048
Crit Care. 2011;15(6):R277
pubmed: 22108136
Diabet Med. 1997 Jan;14(1):29-34
pubmed: 9017350
Chest. 2018 Aug;154(2):317-325
pubmed: 29555594
Shock. 2008 Oct;30(4):434-42
pubmed: 18277945
Br J Pharmacol. 2000 Jul;130(5):963-74
pubmed: 10882379
J Histochem Cytochem. 1982 Dec;30(12):1325-30
pubmed: 6185564
Diabetologia. 2010 Dec;53(12):2646-55
pubmed: 20865240
Am J Pathol. 2019 Aug;189(8):1526-1535
pubmed: 31108101
Am J Physiol Endocrinol Metab. 2001 May;280(5):E685-94
pubmed: 11287350
J Pathol. 2012 Mar;226(4):562-74
pubmed: 22102407

Auteurs

So Sampei (S)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Hideshi Okada (H)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Hiroyuki Tomita (H)

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.

Chihiro Takada (C)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Kodai Suzuki (K)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Takamasa Kinoshita (T)

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.

Ryo Kobayashi (R)

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Hirotsugu Fukuda (H)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Yuki Kawasaki (Y)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Ayane Nishio (A)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Hirohisa Yano (H)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Isamu Muraki (I)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Yohei Fukuda (Y)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Keiko Suzuki (K)

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Nagisa Miyazaki (N)

Department of Internal Medicine, Asahi University School of Dentistry, Mizuho, Japan.

Takatomo Watanabe (T)

Department of Clinical Laboratory, Gifu University Hospital, Gifu, Japan.

Tomoaki Doi (T)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Takahiro Yoshida (T)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Akio Suzuki (A)

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Shozo Yoshida (S)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Shigeki Kushimoto (S)

Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Shinji Ogura (S)

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Classifications MeSH