Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect.

L-arginine Zellweger spectrum disorder autophagy inhibitors chloroquine hydroxychloroquine peroxisomal functions peroxisome biogenesis disorder pexophagy

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 30 01 2021
accepted: 05 03 2021
entrez: 19 4 2021
pubmed: 20 4 2021
medline: 20 4 2021
Statut: epublish

Résumé

Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the

Identifiants

pubmed: 33869228
doi: 10.3389/fcell.2021.661298
pmc: PMC8047214
doi:

Types de publication

Journal Article

Langues

eng

Pagination

661298

Informations de copyright

Copyright © 2021 Klouwer, Falkenberg, Ofman, Koster, van Gent, Ferdinandusse, Wanders and Waterham.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Femke C C Klouwer (FCC)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Department of Pediatric Neurology, Emma Children's Hospital, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Kim D Falkenberg (KD)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Rob Ofman (R)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Janet Koster (J)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Démi van Gent (D)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Sacha Ferdinandusse (S)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Ronald J A Wanders (RJA)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Hans R Waterham (HR)

Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, Netherlands.

Classifications MeSH