Potassium ions promote hexokinase-II dependent glycolysis.
Biochemical Mechanism
Biochemistry
Molecular Physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
23 Apr 2021
23 Apr 2021
Historique:
received:
15
12
2020
revised:
22
02
2021
accepted:
18
03
2021
entrez:
19
4
2021
pubmed:
20
4
2021
medline:
20
4
2021
Statut:
epublish
Résumé
High expression levels of mitochondria-associated hexokinase-II (HKII) represent a hallmark of metabolically highly active cells such as fast proliferating cancer cells. Typically, the enzyme provides a crucial metabolic switch towards aerobic glycolysis. By imaging metabolic activities on the single-cell level with genetically encoded fluorescent biosensors, we here demonstrate that HKII activity requires intracellular K
Identifiants
pubmed: 33870140
doi: 10.1016/j.isci.2021.102346
pii: S2589-0042(21)00314-X
pmc: PMC8047173
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102346Subventions
Organisme : Austrian Science Fund FWF
ID : I 3716
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 28701
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : W 1226
Pays : Austria
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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